talk in hyderabad

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Role of Bioinformatics in the Genomic Era
Limsoon Wong Kent Ridge Digital Labs Singapore
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What are the Themes of Bioinformatics?
Bioinformatics Data Mgmt Knowledge
Discovery Data Mgmt Integration
Transformation Cleansing Knowledge Discovery
Statistics Algorithms Databases
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What are the Benefits of Bioinformatics?

• To the patient
• Better drug, better treatment
• To the pharma
• Save time, save cost, make more
• To the scientist
• Better science

4
Transcription Start Prediction
5
Transcription Start Prediction Results
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Medical Record Analysis

• Looking for patterns that are
• valid
• novel
• useful
• understandable

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Medical Record Analysis Results

• DeEPs, the emerging pattern method
• Beats C4.5, CBA, LB, NB, TAN in 21 out of 32 UCI
  benchmarks
• Works for gene expressions
• ALL vs AML
• DeEPS (1 gene) - 0/38 3/34
• Slonim (50 genes) - 2/38 5/34
• Colon
• DeEPS (35 genes) - 4/62
• Alon (1000 genes) - 6/62

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Genome-Enabled Fruits

• A lot of genes proteins that are
• candidate diagnosis indicators
• candidate prognosis indicators
• candidate drug targets

Whats Next?
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Evaluate Choose the Better Candidates

• Easier to access
• Uncomplicated to modulate
• Clear path to
• Has experience

To do that, you will need to have .
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A Molecular Connections Database consisting of...
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Thank You