Karen H. Rothenberg, J.D., M.B.A.

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Maryland Stem Cell Research Commission
GBC Bioscience Speaker Series
www.mscrf.org May, 28
2009

• Karen H. Rothenberg, J.D., M.B.A.
• Dean and Marjorie Cook Professor of Law at the
  University of Maryland School of Law and Chair,
  Maryland Stem Cell Research Commission

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The Maryland Stem Cell Research Act of 2006

• Purpose The purpose of the Act is to promote
  state-funded stem cell research and cures through
  grants and loans to public and private entities
  in the State.
• Commission Established as an independent unit
  within the Maryland Technology Development
  Corporation (TEDCO), the Commission will
  establish criteria, standards and requirements to
  ensure that stem cell research financed by the
  newly established Maryland Stem Cell Research
  Fund complies with state law.
• Summary To date, 56 million and 141 research
  grants have been funded in the first three years
  and our fourth year of the program with a budget
  of 15.4 million.

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The Maryland Stem Cell Research Act of 2006

• Human Stem Cell Human stem cell is a human cell
  that has the ability to
• (1) Divide indefinitely(2) Give rise to many
  other types of specialized cells(3) Give rise to
  new stem cells with identical potential.
• Including the creation of new stem cell lines.
• Eligibility All Maryland based organizations of
  all types are eligible for the Grants. Such
  organizations include public and private, for
  profit and nonprofit, universities, colleges,
  research institutes, companies, medical centers
  and others.

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Diseases and Conditions
Blood Diseases Schizophrenia Neural Spinal
Cord Injury Central Nervous System Genetic
Development Burn wounds Amyotrophic lateral
sclerosis Multiple peripheral nerve
regeneration Pancreas Neurodegenerative
Diseases Acute myeloid leukemia Multiple
leukemia Brain Tumor Development Lungs
Multiple Cancer Coronary Heart disease
Myocardial infarction Molecular biology Type 1
Diabetes Human pluripotent stem cell Vascular
Neonatal Stroke Retinal degenerative Generate
insulin-producing beta-cells Neural
hematopoiesis Human erythropoiesis Acute
Lymphocytic Leukemia Vascular diseases Brain
pathology Mesenchymal stem Cell Differentiation
Ewing Sarcoma Muscular dystrophy Chronic
pancreatitis, Pancreatic adenocarcinoma
Glioblastoma Parkinson's Disease Cystic
Fibrosis Chemo-resistance Bone Gaucher's
Breast Cancer Osteoarthritis Transplantation
Paroxysmal Nocturnal Hemoglobinuria (PNH) Liver
Alzheimer's Disease Peripheral Arterial Disease
Prostate Cancer
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Investigator-Initiated Research Grants

• Investigator-Initiated Research Grants is
  soliciting applications for Investigator with
  preliminary data supporting the grant application
  with maximum amount of 300,000 a year, for up to
  five years.

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Exploratory Research Grants

• Exploratory Research Grants is soliciting
  applications for Exploratory Research, which are
  designed for investigators who are new to the
  stem cell field and for exploratory projects
  without preliminary data with maximum amount of
  100,000 a year, for up to two years.

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Post-doctoral Fellowship Grants

• Post-doctoral Fellowship Grants is soliciting
  nationwide applications from exceptional
  post-doctoral fellows who wish to conduct
  research on human stem cells in the State of
  Maryland with maximum support of 55,000 a year,
  for up to two years.

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Funding Overview

• Funding started in FY2007 with 15 Million and
  funded 24 research projects
• Investigator-Initiated (7 from 41)
• Exploratory (17 from 45)
• In FY2008 we funded 23 Million and funded 58
  research projects
• Investigator-Initiated (11 from 33)
• Exploratory (32 from 64)
• Post-Doctoral Fellowship (15 from 24)

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Funding Overview Continued

• In FY2009 we funded 18.9 Million in 59 Awards
• Investigator-Initiated Research Grants (6 from
  40)
• Exploratory Research Grants (32 from 70)
• Post-Doctoral Grants (21 from 40)
• In FY2010 we have a budget of 15.4M

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Applications, Grants and budget Summary
MSCRF Budget in Millions
Number of Applications and Awards
2007
2008
2009
2010
Fiscal Year
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FY2009 summary of awards
Awards in Numbers
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FY2009 summary of awards Cont.
Awards in
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FY2009 summary of awards Cont.
Stem Cell Type
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FY2009 summary of awards Cont.
Basic Translational Research
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Strategic Questions

• Enhancing private-public partnerships
• Leveraging State and Federal grants
• Balancing research and capital

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