GoMiner: (Zeeberg et al., Genome Biology, March 2003)

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GoMiner (Zeeberg et al., Genome Biology,
March 2003)
For Tour of GoMiner Advance using forward
arrow
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GoMiner (Zeeberg et al., Genome Biology,
March 2003)
GoMiner is a tool for biological interpretation
of 'omic' data including data from gene
expression microarrays. Omic experiments often
generate lists of dozens or hundreds of genes
that differ in expression between samples,
raising the question, What the h-ll does it all
mean biologically?
To answer that question, GoMiner leverages the
Gene Ontology (GO) to classify the genes into
biologically coherent categories and assess those
categories statistically.
For biological interpretation of a microarray
experiment, the user enters the list of genes on
the array and has the option of flagging them as
up-regulated, down-regulated, or neither with
respect to some index standard.
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GoMiner (Zeeberg et al., Genome Biology,
March 2003)
This animation presents a tour of the highlights
of GoMiners functionality and user interface.
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GoMiner (Zeeberg et al., Genome Biology,
March 2003)
Fishers Exact p-Value for All Changed Genes in
Category
Relative Enrichment of Overexpressed Genes In
Category
Relative Enrichment of Underexpressed Genes In
Category
Relative Enrichment of All Changed Genes in
Category
Total Genes in Category
An Underexpressed Gene
An Overexpressed Gene
An Unchanged Gene
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GoMiner (Zeeberg et al., Genome Biology,
March 2003)
Results can also be exported for further analysis
with other tools
Click on a gene to link Out to Major
Molecular Biology Databases
BioCarta _at_ CGAP
Entrez Genome _at_ LocusLink
NCBI-Structures
GeneCards
PubMed
MedMiner
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GoMiner has an additional visualization based on
a Directed Acyclic Graph (DAG) view of your
experiment results and GO
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Categories with an enrichment of changed genes
The relationships between the GO categories
Mouse over a category to see the genes that have
been assigned there
Categories with a depletion of changed genes
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Visit http//dicover.nci.nih.gov/gominer to
download and start using GoMiner