ENVIRONMENTAL AND NONENVIRONMENTAL FACTORS AFFECTING TOXICITY

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ENVIRONMENTAL AND NON-ENVIRONMENTAL FACTORS
AFFECTING TOXICITY

• Suggested reading
• Hodgson, E. and Levi, P.E. Metabolism of
  Pesticides, In Handbook of Pesticide Toxicology,
  Krieger, R. ed. Vol 1, p 542-551.

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Time course of induction
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Induction can be observed by bioassay

• Southern armyworm

a2000 PPM in diet Brattsten and Wilkinson 1973,
Pestic. Biochem. Physiol. 3393-407
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Induction can be observed using enzyme activity
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Induction can be observed by monitoring total P450
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Induction can be observed by monitoring
individual P450s