Systemic Lupus Erythematosus SLE

1
Systemic Lupus Erythematosus (SLE)

• Dana Gais

2
Autoimmune Diseases

• Autoimmune Disease
• Systemic Autoimmune Disease
• Responses seen in SLE
• Autoantibodies found in SLE

3
Systemic Lupus Erythematosus

• Course of Disease Causes of Death
• Clinical Symptoms
• What causes these symptoms?

4
What Causes SLE

• Cause is unknown
• Possible factors
• Genetic
• Environmental

5
What Happens?

• Loss of self-non-self recognition
• Diversification of antigen-driven responses
• Hyperactivity of T B Cells
• Formation of immune complexes
• Type III hypersensitivity reaction

6
Loss of T-cell Tolerance

• T-Cells found in
• healthy diseased patients
• Loss of self-non-self recognition allows
• T-Cells to react
• with self antigen

7
Pathogenesisonce T-cell tolerance is lost
8
Type III Hypersensitivity Reaction(Immune
Complex-Mediated)

• Hyperactivity of T and B-cells
• Formation of immune complexes
• Clearance via the complement system
• Type III Hypersensitivity Reaction
• Tissue damage

9
Therapies for SLE

• 1st Therapies
• Cytotoxic drugs
• Current Therapies
• Immunosuppressions
• Cyclophosphamide
• Mycophenolate Mofetil
• Future Therapies
• Hormonal modulation
• Cytokine inhibition

10
Key Concepts

• Self-non-self
• Specificity
• Memory

11
References

• Baechler E, Gregersen P, Behrens T. 2004. The
  emerging role of interferon in human systemic
  lupus erythematosus. Current Opinion in
  Immunology 16 801-807.
• Blatt N, Glick G. 1999. Anti-DNA autoantibodies
  and systemic lupus erythematosus. Pharmacology
  and Therapeutics 83 125-139.
• Brogan P, Dillon M. 2005. Autoimmune diseases in
  children. Current Paediatrics 15 23-31.
• Franchin G, Peeva E, Diamond B. 2004.
  Pathogenesis of SLE implications for rational
  therapy. Drug Discovery Today Disease Mechanisms
  1 303-308.
• Hoffman R. 2004. T cells in the pathogenesis of
  systemic lupus erythematosus. Clinical Immunology
  113 4-13.
• Kaplan M. 2004. Apoptosis in systemic lupus
  erythematosus. Clinical Immunology 112 210-218.
• Renaudineau Y, Pers J, Bendaoud B, Jamin C,
  Youinou P. 2004. Dysfunctional B cells in
  systemic lupus erythematosus. Autoimmunity
  Reviews 3 516-523.
• Sidiropoulos P, Bertsias G, Kritikos H, Boumpas
  D. 2004. Therapeutic strategies for refractory
  systemic lupus erythematosus. Drug Discovery
  Today Therapeutic Strategies 3 375-382.
• Singh R. 2004. Prevention and control of
  reciprocal T-B cell diversification implications
  for lupus-like autoimmunity. Molecular Immunology
  40 1137-1145.
• Tsukamoto H, Horiuchi T, Kokuba H, Nagae S,
  Nishizaka H, Sawabe T, Harashima S, Himeji D,
  Koyama T, Otsuka J, and others. 2005. Molecular
  analysis of a novel hereditary C3 deficiency with
  systemic lupus erythematosus. Biochemical and
  Biophysical Research Communications 330 298-304.