Hepatitis B Virus

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Hepatitis B Virus
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Immunology Antibodies
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Models for recombination of Ig genes V and J. A.
Deletional joining occurs when the gene segments
have the same transcriptional orientation (blue
arrows). B. Inversional joining occurs when the
gene segments have opposite transcriptional
orientations.
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Class switching
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The T-Cell Receptor

• Variations on a Theme by Molecules of the Ig
  Superfamily!

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Structural similarities between Ig and TCR.
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Overview of TCR Recombination
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Production and Identification of cDNAs coding
the TCR by subtractive hybridization.
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Germ-line organization of murine TCR genes.
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Gene Rearrangements
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Affinity constants and Roles of Co-receptors in
TCR binding.
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TCR-MHC-peptide structures.
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TCR-MHC-peptide structures --top view with TCR a
(red) and ß (yellow) variable regions.
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HIV buds out of cells.
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VVP Fig. 27-42 Heme controlled protein synthesis
in reticulocytes.