Metabolism of Sugars Besides Glucose

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Metabolism of Sugars Besides Glucose

• Chap 17

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The Sugars
CHO
CH2OH
CHO
CHO
O
CH2OH
CH2OH
CH2OH
CH2OH
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Fructose

• In Muscle
• Hexokinase to Fructose 6 P
• In Liver
• Hexokinase has low expression replaced by
  glucokinase specific for Glucose
• Fructokinase F-1-P --gt F-1-P aldolase
• Resultant DHAP goes directly to Glycolysis
• GA can either be phosporylated directly or be
  converted to DHAP then glycolysis

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The Sugars
CHO
CH2OH
CHO
CHO
O
CH2OH
CH2OH
CH2OH
CH2OH
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Manose

• Hexokinase
• Phosphomanose Isomerase
• Same mechanism as Phosphoglucoisomerase and TIM
  reversed stereo chemistry.

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Page 588
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The Sugars
CHO
CH2OH
CHO
CHO
O
CH2OH
CH2OH
CH2OH
CH2OH
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Page 621
Figure 17-36 Metabolism of galactose
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