Pediatric Clinical

1
Pediatric Clinical Translational Research
Center (PCTRC)

• University of Pittsburgh
• Clinical and Translational Science Award

CTSA Pediatric Steering Committee Bethesda,
MD March 22, 2007
2
Integration of Pediatric Research into CTSA

• Since 1962 the Childrens Hospital of Pittsburgh
  GCRC had a historically successful clinical and
  translational research program before the CTSA.
• CTSA provides a range of participant recruitment
  and clinical interaction resources (PCIR) that
  support translational patient-oriented research
  in pediatrics.
• CTSA provides additional resources through
  collaboration with the CTSI Center for Clinical
  and Translational Informatics (CCTI) (data
  management, statistical support etc.) and pilot
  funding.
• CTSA provides extensive educational opportunities
  that support the research activities of pediatric
  junior faculty and trainees enrolled in CTSI
  training programs.
• CTSA provides institutional support for
  large-scale community-based pediatric research
  outside the PCTRC.
• The CTSA will facilitate the development of
  interdisciplinary research.

3
Key Challenges for Pediatric Research

• Institutional Review Boards (IRB)
• IRB restrictions hinder meritorious
  pediatric research
• Need for uniformity and standardization
  across IRBs
• Shrinking pool of pediatric physician-investigator
  s
• Lack of K funding opportunities for International
  Medical Graduates.
• Dwindling NIH funding despair of
  investigators
• Junior investigators we dont want
  this kind of lifestyle!
• Senior investigators when can I
  retire?
• The notion that adults are good models for
  diseases that affect children and adults is
  wrong. Research in pediatrics should not be
  swallowed up by research in adults.

4
Goals for the Pediatric Steering Committee Meeting

• Identify problems within the larger structure of
  the CTSA to insure that pediatric research is not
  unfairly compromised in favor of other CTSA
  activities/programs.
• To develop qualitative and quantitative processes
  for comprehensively evaluating and tracking the
  success of pediatric research within the CTSA and
  pediatric investigators needs.
• Work with NIH to develop a timetable to address
  and successfully overcome the above stated key
  challenges for pediatric research.

5
Pediatric Clinical Translational Research
Center (PCTRC)

• University of Pittsburgh
• Clinical and Translational Science Award

CTSA Pediatric Steering Committee Bethesda,
MD March 22, 2007
6
Participant and Clinical Interaction Resources
Core Organization
CTSI Executive Committee
Director, PCIR Core
Administrative Director, PCIR
Administrative Coordination Committee, PCIR
Education
Participant and Clinical Interaction Resources
Informatics
Childrens Hospital CTRC
Montefiore University Hospital CTRC
Pittsburgh Cancer Institute CTRC
Regulatory
Magee Womens CTRC
Neuroscience CTRC
Community CTRC
Technologies