Molecular Imaging

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Molecular Imaging

• Hendrik de Leeuw
• Vincent Boer

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Overview

• What is Molecular Imaging?
• Applications
• Techniques
• Conclusion

Vincent Hendrik
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What is Molecular Imaging?

• Molecular map of a whole organ?

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What is Molecular Imaging?

• Molecular Imaging targets the biochemical changes
  of diseases, which often occur a long time before
  the morphological expressions
• Used for early imaging of cancer or coronary
  artery disease (CAD)
• Always uses certain probe molecules or probe

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What is Molecular Imaging?

• A better name would be
• functional imaging
• or
• probe imaging

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Genetic predisposition
DNA mutations
Developing molecular signature
First symptoms
Progressing disease

• Diagnostic imaging
• Unspecific marker

Follow-up
Diagnosis Staging
Treatment Monitoring
Today
Screening

• Mammography
• POS imaging
• Unspecific markers

• Diagnostic imaging
• Biopsies

• Surgery
• Cath lab
• Radiation therapy

Treatment Monitoring
Diagnosis Staging
Follow-up
Tomorrow
Screening

• Non-invasive and quantative imaging
• Molecular imaging
• Molecular diagnostics

• Min. Invasive surgery
• Local/targeted drug
• delivery
• Drug tracing
• Tissue analysis

• Molecular imaging
• Quantitative imaging
• Whole-body imaging
• Computer Aided diag.

• Specific markers

Progress of disease
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Techniques

• fMRI
• PET
• Ultra Sound
• Optical Imaging (Nanoshell Imaging)

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Ultra Sound
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Nanoshell Imaging
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Problems

• However
• Finding probe is difficult
• Long term effects?

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Futuristics

• Combined targeted imaging and treatment
• Treat more
• Treat earlier
• Thus.Treat better

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Conclusions

• Earlier, more accurate diagnosis
• Growing field
• Multi field science
• Promising field of research