MICROHOPE: ACEI improves renal and CV outcomes in diabetes

1
MICRO-HOPE ACEI improves renal and CV outcomes
in diabetes
N 3577 (32 with microalbuminuria)
Overt nephro-pathy
Mean albumin/ creatinine ratio
CV death
P 0.02
Stroke
MI
0
3.0
Placebo
-10
2.0
Relative risk reduction ()
Ramipril 10 mg
-20
1.0
P 0.001 at 1 yr
-30
P 0.01
P 0.027
0
-40
0
1
2
3
4.5
P 0.007
Years
P 0.0001
P values ACEI vs placebo
HOPE Study Investigators. Lancet. 2000355253-9.