An Overview of NIHs Center for Scientfic Review

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An Overview of NIHs Center for Scientfic Review
Peter J. Perrin, Ph.D. Center for Scientific
Review National Institutes of Health U.S.
Department of Health and Human Services
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Transforming medicine through discovery
NIH
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NIH Mission Statement

• NIH is the steward of medical and behavioral
  research for the Nation. Its mission is science
  in pursuit of fundamental knowledge about the
  nature and behavior of living systems and the
  application of that knowledge to extend healthy
  life and reduce the burdens of illness and
  disability.

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Coronary Heart Disease Age-Adjusted Death Rates
in U.S. Actual (blue) vs. Expected (yellow)
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U. S. Department of Health and Human Services
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National Institutes of Health
Office of the Director
National Institute on Alcohol Abuse and Alcoholism
National Institute of Arthritis
and Musculoskeletal and Skin Diseases
National Cancer Institute
National Institute on Aging
National Institute of Child Health and
Human Development
National Institute of Allergy and Infectious
Diseases
National Institute of Diabetes and Digestive
and Kidney Diseases
National Institute of Dental and Craniofacial Rese
arch
National Institute on Drug Abuse
National Institute of Environmental Health
Sciences
National Institute on Deafness and
Other Communication Disorders
National Eye Institute
National Human Genome Research Institute
National Heart, Lung, and Blood Institute
National Institute of Mental Health
National Institute of Neurological Disorders
and Stroke
National Institute of General Medical Sciences
National Institute of Nursing Research
National Library of Medicine
National Center for Complementary and
Alternative Medicine
National Center on Minority Health and Health
Disparities
National Institute of Biomedical Imaging and
Bioengineering
Fogarty International Center
National Center for Research Resources
Center for Information Technology
Center for Scientific Review
Clinical Center
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A Typical Institute/Center
Office of the IC Director
National Advisory Council
Board of Scientific Counselors
Extramural
Intramural
Scientific Programs
Laboratory Studies
Clinical Studies
Grants
Contracts
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NIH Extramural Program

• Grant Patron
• (assistance, encouragement)
• Cooperative Partner
• Agreement (assistance but substantial
• program involvement)
• Contract Purchaser
• (procurement)

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Funding Proposed for HHS Health Programs in Bush
Administrations FY 2006 Budget
Total 592 Billion
Total 52.6 Billion
HRSA11
CDC 8
FDA 3
Medicare 58
Health Discretionary Programs 9
NIH54
Medicaid 33
Other 24
SCHIP 1
HHS, Budget in Brief FY 2006, February 2005.
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NIH Budget in FY 2006 is 28.6 Billion
Spending at NIH 4.8 B
Spending Outside NIH 23.8 B
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Balanced National Biomedical Research Portfolio
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Overall Peer Review Process
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CSR Mission Statement

• To see that NIH grant applications receive fair,
  independent, expert, and timely reviews -- free
  from inappropriate influences -- so NIH can fund
  the most promising research.

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Center for Scientific Review

• Functions
• Provides support to Office of Director, NIH, in
  formulating grant application review policies and
  procedures
• Receives, processes, and refers applications
  submitted to NIH and some other DHHS agencies
• Provides scientific merit review of applications
  submitted to NIH

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Dual Review System for Grant Applications

• First Level of Review
• Scientific Review Group (SRG)
• Provides Initial Scientific Merit
• Review of Grant Applications
• Rates Applications and Makes
  Recommendations for Appropriate Level of Support
  and Duration of Award

• Second Level of Review
• Council
• Assesses Quality of SRG
• Review of Grant Applications
• Makes Recommendation to
• Institute Staff on Funding
• Evaluates Program Priorities
• and Relevance
• Advises on Policy

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Review Process for a Research Grant
National Institutes of Health
Research Grant Application
School or Other Research Center
Center for Scientific Review
Assigns to IRG/Study Section IC
Study Section
Initiates Research Idea
Submits Application
Evaluates for Scientific Merit
Institute
Evaluates for Program Relevance
Advisory Councils and Boards
Allocates Funds
Conducts Research
Recommends Action
Institute Director
Takes final action for NIH Director
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Peer Review of NIH Support Mechanisms
Reviews by CSR, the Institutes and CSR, or the
Institutes

• Research Project Grant (R01)
• Small Business Grants (R41, R42, R43, R44)
• Individual Fellowships (F30, F31, F32, F33, etc.)
• Exploratory/Development Grants (R21, R33,
  R21/R33)
• Shared Instrumentation Grant (S10)
• Academic Research Enhancement Award (R15)
• Resource Grants (P40, P41, R24, R26, R28)

• Requests for Applications (RFAs)
• Program Project Grant (P01)
• Development Awards (K01, K02, K05, K07, K08, K23,
  K24, etc.)
• Small Grants (R03)
• Center Grants (P30, P50, P60)
• Conference Grants (R13)
• Institutional Training Awards (T32, T35)
• MARC (F34, F36, T34)
• Minority Biomedical Support Grant (S06)
• Contracts

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NIH Referral and Review Process
Program and Policy Considerations
NIGMS
NIA
NINDS
NIAAA
NIAID
Referral Review
NEI
NIDCR
NIAMS
CSR
NIMH
NINR
NHLBI
NIEHS
NHGRI
NIDCD
Scientific Management
NCCAM
NICHD
NLM
Funding Decisions
NIDDK
NCRR
NIDA
NCMHD
NIBIB
NCI
FIC
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CSR Receipt and Referral Central
Receipt Point for Applications
submitted to the Public Health Service
National Institutes of Health
Substance Abuse and Mental Health
Services Administration
CSR Receipt Referral
Agency for Health Care Policy Research
Centers for Disease Control
Office of Assistant Secretary for Health
Food Drug
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CSR Organization
Office of the Director (OD)Dr. Toni Scarpa,
Director
DMCMDivision of Molecular Cellular Mechanisms
DBBDDivision of Biological Basis of Disease
DMSDivision of Management Services
Administrative Services Branch
DCPBSDivision of Clinical Population Based
Studies
Travel and Consultant Reimbursement Section
DPPDivision of Physiology Pathology
Committee Management Branch
Financial Management Branch
DRRDivision of Receipt Referral
Technology Services Branch
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CSR Review Divisions
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Digestive Sciences IRG

• Gastrointestinal, liver and pancreatic physiology
  and pathology
• Nutrients and xenobiotics action and disposition

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Gastrointestinal Mucosal Pathobiology

• GI mucosal immunology
• HostPathogen interactions
• GI epithelial cell biology
• In vitro, animal, and human models of
  inflammatory bowel diseases, enteric infections,
  and intestinal injury repair
• Applications reviewed for NIDDK, NIAID, NCI,
  NCCAM, NIEHS, NIAAA, NICHD, and NHLBI