Detection of Ziram by LC/APCI/MS

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Detection of Ziram by LC/APCI/MS Hiroshi
MORIWAKI Osaka City Institute of Public Health
Environmental Sciences
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Ziram
use
pesticide antifouling agent
toxicity
endocrine disruptor mutagen carcinogen
((CH3)2NCS.S)2Zn M.W. 305.8 m.p. 240 Log Pow 1.09
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Analysis of Ziram
Direct detection by GC/MS ?
Conventional method
Decomposition of the ligand to CS2

Chemical speciation of dithiocarbamate pesticides
LC/MS ( Direct detection of ziram )
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Ion mode
Ionization
Positive ion mode
Negative ion mode
ESI/MS



APCI/MS
Corona currentlt0.6mA

?
Corona currentgt0.6mA
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Mass spectrum
B)
A)
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Corona current vs. peak intensity
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Cone voltage vs. peak intensity
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Conditions of APCI/MS
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Column separation
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Mass chromatogram
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Calibration curve
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Summary Direct detection of Ziram by
LC/APCI/MS Corona current gt 0.6mA LC
separation GPC column Instrumental detection
limit 2mg/L
Next step Development of the pretreatment
Use of LC/MS/MS
ref. H. Moriwaki, Y. Yamaguchi and M.
Fukushima Rapid Commun. Mass Spectro., in press
(2001).