LUNG TRANSPLANTATION

1
LUNG TRANSPLANTATION

• Pediatric Recipients

ISHLT
2009
2
RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG
RECIPIENTS - NUMBER (Transplants January 1986 -
June 2008)
ISHLT
Analysis includes living donor transplants
2009
3
RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG
RECIPIENTS - PERCENTAGE(Transplants January
1986 - June 2008)
ISHLT
Analysis includes living donor transplants
2009
4
DONOR TYPE DISTRIBUTION BY YEAR OF TRANSPLANT FOR
PEDIATRIC LUNG RECIPIENTS (Transplants 1986-2007)
NOTE This figure includes only the lung
transplants that are reported to the ISHLT
Transplant Registry. As such, the presented data
may not mirror the changes in the number of lung
transplants performed worldwide.
ISHLT
2009
Analysis includes living donor transplants
5
DONOR TYPE DISTRIBUTION BY RECIPIENT AGE GROUP
WITHIN ERA FOR PEDIATRIC LUNG RECIPIENTS
(Transplants January 1986 - June 2008)
ISHLT
Analysis includes living donor transplants
2009
6
AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG
RECIPIENTS (Transplants January 1986 - June 2008)
ISHLT
2009
7
AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTSBy
Year of Transplant
NOTE This figure includes only the pediatric
lung transplants that are reported to the ISHLT
Transplant Registry. Therefore, these numbers
should not be interpreted as the rate of change
in pediatric lung procedures performed worldwide.
ISHLT
2009
Analysis includes living donor transplants

8
NUMBER OF CENTERS REPORTING PEDIATRIC LUNG
TRANSPLANTS
ISHLT
Analysis includes living donor transplants
2009

9
NUMBER OF CENTERS REPORTING PEDIATRIC LUNG
TRANSPLANTS BY CENTER VOLUME
ISHLT
Analysis includes living donor transplants
2009

10
PEDIATRIC LUNG TRANSPLANTATION Indications
(Transplants January 1990 June 2008)
ISHLT
Analysis includes living donor transplants
2009

11
PEDIATRIC LUNG TRANSPLANTATIONOther Indications
(Transplants January 1990 June 2006)
ISHLT
Analysis includes living donor transplants
2009
Last updated based on data as of December 2006

12
PEDIATRIC LUNG TRANSPLANTATION Other
Indications (Transplants January 1990 June
2006)
ISHLT
Analysis includes living donor transplants
2009
Last updated based on data as of December 2006

13
PEDIATRIC LUNG TRANSPLANTATION Other
Indications (Transplants January 1990 June
2006)
ISHLT
Analysis includes living donor transplants
2009
Last updated based on data as of December 2006

14
DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTSBY YEAR OF
TRANSPLANTAge 12-17 Years
ISHLT
Analysis includes living donor transplants
2009

15
PEDIATRIC LUNG TRANSPLANTSAGE DISTRIBUTION BY
LOCATION Transplants between January 2000 and
June 2008
ISHLT
Analysis includes living donor transplants
2009

16
PEDIATRIC LUNG TRANSPLANTSDIAGNOSIS
DISTRIBUTION BY LOCATION Transplants between
January 2000 and June 2008
NOTE Unknown diagnoses were excluded from this
tabulation. Total number of transplants
reported Europe 171 North America 443 Other
35
ISHLT
2009

Analysis includes living donor transplants
17
PEDIATRIC LUNG TRANSPLANTSDONOR AGE
DISTRIBUTION BY LOCATION Transplants between
January 2000 and June 2008
NOTE Transplants with unknown donor age and
living donor transplants were excluded from this
tabulation. Total number of transplants
reported Europe 181 North America 443 Other
35
ISHLT
2009

18
LUNG TRANSPLANTATIONKaplan-Meier Survival by Age
Group (Transplants January 1990 - June 2007)
ISHLT
2009

19
PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier
Survival by Procedure Type (Transplants January
1990 - June 2007)
ISHLT
2009

20
PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier
Survival for Congenital Diagnoses (Transplants
January 1990 June 2007)
ISHLT
2009

21
PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier
Survival by Age Group (Transplants January 1990
- June 2007)
ISHLT
2009

22
PEDIATRIC LUNG TRANSPLANTATIONConditional
Kaplan-Meier Survival by Age Group(Transplants
January 1990 - June 2007)
ISHLT
2009

23
PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier
Survival by Era (Transplants January 1988 - June
2007)
ISHLT
2009

24
PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier
Survival by Donor Type for Recipients Age 12-17
Years(Transplants January 1990 - June 2007)
ISHLT
2009

25
PEDIATRIC LUNG RE-TRANSPLANTS Between January
1994 and June 2008
Time Between Previous and Current Transplant
ISHLT
2009

26
PEDIATRIC LUNG RETRANSPLANTSSurvival for
Transplants Performed Between January 1994 and
June 2007
ISHLT
2009

27
PEDIATRIC LUNG RECIPIENTS Functional Status of
Surviving Recipients(Follow-ups April 1994-June
2008)
ISHLT
2009

28
PEDIATRIC LUNG RECIPIENTS Functional Status of
Surviving RecipientsFor the Same
Patients(Follow-ups April 1994-June 2008)
ISHLT
2009

29
PEDIATRIC LUNG RECIPIENTS Rehospitalization
Post-transplant of Surviving Recipients(Follow-up
s April 1994 - June 2008)
ISHLT
2009

30
PEDIATRIC LUNG RECIPIENTS Rehospitalization
Post-transplant of Surviving Recipients(Follow-up
s April 1994 - June 2008)
ISHLT
2009

31
PEDIATRIC LUNG RECIPIENTS Induction
ImmunosuppressionFor transplants between January
2001 and June 2008
ISHLT
Analysis is limited to patients who were alive at
the time of the follow-up
2009

32
PEDIATRIC LUNG RECIPIENTSInduction
Immunosuppression (Transplants January 2001 -
June 2007)
ISHLT
Analysis is limited to patients who were alive at
the time of the follow-up
2009

33
PEDIATRIC LUNG TRANSPLANTATIONKaplan-Meier
Survival Stratified by Induction Use
(Transplants January 2001 - June 2007)
ISHLT
2009

34
PEDIATRIC LUNG RECIPIENTS Maintenance
Immunosuppression at Time of Follow-up(Follow-ups
January 2001 June 2008)
NOTE Different patients are analyzed in Year 1
and Year 5
ISHLT
Analysis is limited to patients who were alive at
the time of the follow-up
2009

35
PEDIATRIC LUNG RECIPIENTS Maintenance
Immunosuppression at Time of Follow-up(Follow-ups
January 2001 June 2008)
1 Year Follow-up (N 272)
5 Year Follow-up (N 117)
NOTE Different patients are analyzed in Year 1
and Year 5
NOTE 4 of patients were on both calcineurin
inhibitors at different point during the year
these patients are not counted in either group.
And 1 (2 patients) was on neither drugs during
the year. In the 5-year tabulations, 13 were
reported to be on both drugs during the year and
1 (1 patient) was reported to be on neither
drugs.
ISHLT
2009

Analysis is limited to patients who were alive at
the time of the follow-up
36
PEDIATRIC LUNG RECIPIENTS Maintenance
Immunosuppression Drug Combinations at Time of
Follow-up Report (Follow-ups January 2001
June 2008)
NOTE Different patients are analyzed in Year 1
and Year 5
ISHLT
Analysis is limited to patients who were alive at
the time of the follow-up
2009

37
POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS
Cumulative Prevalence in Survivors within 1 Year
Post-Transplant (Follow-ups April 1994 - June
2008)
ISHLT
2009

38
POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS
Cumulative Prevalence in Survivors within 5
Years Post-Transplant (Follow-ups April 1994 -
June 2008)
ISHLT
2009

39
POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS
Cumulative Prevalence in Survivors within 7
Years Post-Transplant (Follow-ups April 1994 -
June 2008)
ISHLT
2009

40
Freedom from Bronchiolitis Obliterans Syndrome
For Pediatric Lung Recipients (Follow-ups April
1994 - June 2008)
ISHLT
2009

41
Freedom from Bronchiolitis Obliterans Syndrome
For Pediatric Lung Recipients by Induction Use
(Follow-ups April 1994 - June 2008)
ISHLT
2009

42
Freedom from Severe Renal DysfunctionFor
Pediatric Lung Recipients (Follow-ups April 1994
- June 2008)

ISHLT
2009

43
MALIGNANCY POST-LUNG TRANSPLANTATION FOR
PEDIATRICSCumulative Incidence for Survivors
(Follow-ups April 1994 - June 2008)
Other includes Liver and primitive
neuroectodermal tumor.
ISHLT
2009

44
Freedom from MalignancyFor Pediatric Lung
Recipients (Follow-ups April 1994 - June 2008)
ISHLT
2009

45
PEDIATRIC LUNG TRANSPLANT RECIPIENTS Cause Of
Death(Deaths January 1992- June 2008)
ISHLT
2009

46
PEDIATRIC LUNG TRANSPLANT RECIPIENTS Other Cause
Of Death(Deaths January 1992- June 2006)
ISHLT
2009
Last updated based on data as of December 2006

47
PEDIATRIC LUNG TRANSPLANT RECIPIENTS Relative
Incidence of Leading Causes of Death (Deaths
January 1992 - June 2008)
ISHLT
2009


48
PEDIATRIC LUNG TRANSPLANT RECIPIENTS
(1/1990-6/2007) Risk Factors For 1 Year
Mortality/Graft Failure
N738
ISHLT
2009

49
PEDIATRIC LUNG TRANSPLANT RECIPIENTS
(1/1990-6/2003) Risk Factors For 5 Year
Mortality/Graft Failure
N527
ISHLT
2009