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Probiotics and prebiotics in the newborn

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Probiotic: A live microbial food supplement that beneficially affects the host ... Caesarian section. Gronlund et al, JPGN; 1999;28:19-25 ... – PowerPoint PPT presentation

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Title: Probiotics and prebiotics in the newborn


1
Probiotics and prebiotics in the newborn
  • Alison Bedford Russell
  • Consultant Neonatologist
  • Birmingham Heartlands

2
Probiotics and pre-biotics
  • Probiotic A live microbial food supplement that
    beneficially affects the host by alteration of
    its intestinal microbial balance
  • Prebiotic Non-digestible food ingredient that
    beneficially affects the host by stimulating the
    growth or activity of one or more bacterial
    species already present in the gut

3
(No Transcript)
4
Kraehenbull Corbett, Science,2004 3031624-162
5 Macpherson Uhr, Science, 20043031662- 1624
5
Hooper et al, 2001
6
Normal microflora of the newborn
  • E.coli Enterococcus spp first
  • Bifidibacterium over next 5 days
  • Heterogenous bacterial flora by day 10
  • Bifidobacteria lactobacilli predominate in
    breastfed
  • Mixed in formula

Knol et al Arch Dis Child,200184A22
JPGN,200031S26
7
Factors affecting initial colonisation
  • Broad-spectrum antibiotics
  • Bennet et al, Pediatr Infect Dis,865533-9
  • Breast vs Formula
  • Hall et al, Arch Dis Child 199065185-8
  • Caesarian section
  • Gronlund et al, JPGN 19992819-25
  • Separation of mother and baby on first night
  • Montgomery et al Allergy 200055916-22

8
Probiotic effects
  • Different probiotics have different actions
  • Modify bacteria from pathogenic to benign
  • Possible increase in maturation and development
    of gut and gut function
  • Reduction in allergy
  • Kalliomaki et al, Lancet,20013571076-1079

9
BJOG,20061131-8
10
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