4TH MEETING OF TECHNOLOGICAL NETWORK ON HIVAIDS

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4TH MEETING OF TECHNOLOGICAL NETWORK ON HIV/AIDS

• Rio de Janeiro, Brazil Dec 10-14, 2007

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Representatives from Thailand

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• 2. ??. ?????????? ????????
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8 countries in the network

• China, Cuba, Russia, Thailand, Ukraine,
  Argentina, Brazil and Nigeria

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The main objectives of the network

• To make HIV drugs accessible and affordable for
  all.
• To develop and produce HIV tests, CD4 cell count
  tests, viral load tests, and genotyping.

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Roles and Activities of the network

• To establish potential partnerships in order
  to encourage/facilitate information sharing and
  technology transfer for API production, ARV
  formulation and laboratory infrastructure
• 3 Meetings held
• 1st in Brazil, January 2005, 2nd in Shanghai,
  August 2005 and 3rd in Cuba, June 2006

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2 Workshops

• Biological processes

• ARV formulation and API production

• Genotype samples-Resistance and Surveillance
• Quality control-Serology (Diagnostic Kits )
• Quality Control-Viral load

• Information sharing strategic ARV drugs,
  infrastructure
• Problem discussion
• Technical bottle neck
• Drafting proposals

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Strategic ARV drugs

• Tenofovir DF
• Emtricitabine

Lamivudine
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Strategic ARV drugs (continued)

• Efavirenz
• Ritonavir/Lopinavir

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Strategic ARV drugs (continued)

• Atazanavir
• Abacavir

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ARV drugs under patents
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Cooperation between country members

• Cooperation project on formulation development
• Analytical methodology
• Stability studies
• Physical and chemical test, bioequivalent studies
• Technical consultancy

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Focused ARV drugs

• Tenofovir
• Atazanavir
• Abacavir
• Lopinavir/r (Heat stable) for both adult and
  pediatric formulation
• Ritonavir (Heat stable)
• Fixed dose combination
• (i.e. LamivudineEfavirenzTenofovir,
  EmtricitabineTenofovirEfavirenz and Lamivudine
  Zidovudine, LamivudineZidovudineNevirapine for
  Pediatric)

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Action plan
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The Institute of Pharmaceutical Technology
Farmanguinhos

• The Replace Laboratory of the Brazilian Ministry
  of Health
• GMP (Certificate by National agency)
• ARV, Antibiotic, Analgesic, Diabetics,
  Cardiovascular, Respiratory, Antimalaria
  medicines
• DDI, Stavudine, Lamivudine, Nevirapine and
  Lamivudine/AZT
• 65 of Budget from Brazil Government for Second
  line drug (Lopinavir/r, Efavirenz and Saquinavir)
• Technology transfer (i.e Production of ARV, ARV
  Plant with Nigeria and Mozambique

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Next Meeting

• Thailand 2008

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WORK
SHOP
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The Institute of Pharmaceutical Technology
Farmanguinhos
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Christ of Redeemer
Sugar Loaf
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