Anterior Pituitary

1
Anterior Pituitary

• Lindsey.elmore_at_ucsf.edu

2
Be able to match each hypothalamic hormone with
the anterior pituitary hormone it regulates and
tell whether the action of the regulator is
stimulatory or inhibitory.
3
Know the clinically available drugs related to
the hypothalamic and anterior pituitary and their
possible uses.

• Somatostatin anti-growth hormone
• Octreotide used to treat acromegalia
• Protirelin Thyrotropin releasing hormone (useful
  for diagnostic purposes)
• Leuprolide and other congeners treats prostate
  CA and endometriosis
• Somatropin Recombinant GH
• Sermorelin GHRH
• Mecasermin IGF-1
• Bromocriptine, pergolide, and cabergoline PRL
  release inhibitors
• Cosyntropin ACTH

4
When you study focus on somatostatin, TRH, and
GnRH
5
Octreotide

• There are 5 receptor subtypes for somatostatin
  and there are drugs in development for each of
  the receptors.
• Used to treat acromegalia by inhibiting GH release

6
Be able to recognize the role of peptide
modifications at the termini of TRH.

• Lactam and amide on the end of molecule protects
  it from degradation.

7
For GnRH, know the function and modifications
used to provide more potent agonists.
8
Prolactin Release Inhibitors

• Used to treat hyperprolactinemia which may lead
  to hypogonadism. Treats conditions where
  lactation needs to be inhibited.

9
Describe the POMC family.