Schematic Representation of the GABAB Receptor

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Schematic Representation of the GABAB Receptor
SIGMA-ALDRICH
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Schematic Representation of the GABAB
Receptor Representation of the GABAB receptor
heterodimer which is composed of two, seven
transmembrane-spanning units that are linked by
their carboxyl-termini. The apparent ligand
binding domains are on the extracellular surface
of R1 and R2. Activation of the heterodimer
modulates adenyl cyclase activity via G-proteins
that, in addition, influence K and Ca2
conductances. References Marshall, F.H., et al.,
GABAB receptors - the first 7TM heterodimers.
Trends Pharmacol. Sci., 20, 396-399
(1999). Couve, A., et al., GABAB receptors a
new paradigm in G protein signaling. Mol. Cell.
Neurosci., 16, 296-312 (2000).