Study questions

1
Study questions
A patient weighing 75 kg is given acetaminophen
at a dose of 0.13 mg/kg. After the drug has been
completely absorbed, a blood sample is taken and
the concentration of drug is 0.143 mg/L. What
was the volume of distribution? a. 0.013 b.
0.9 c. 1.1 d. 2
2
Study questions
A patient weighing 75 kg is given acetaminophen
at a dose of 0.13 mg/kg. After the drug has been
completely absorbed, a blood sample is taken and
the concentration of drug is 0.143 mg/L. What
was the volume of distribution? a. 0.013 b.
0.9 c. 1.1 d. 2 Answer Vd Q/Cp
0.13 mg/kg / 0.143 mg/L 0.91 L/kg
3
If total body water is 0.5 L/kg, does
acetaminophen partition into a. plasma only b.
extracellular fluid only c. total body water
only d. total body water plus fat
4
If total body water is 0.5 L/kg, does
acetaminophen partition into a. plasma only b.
extracellular fluid only c. total body water
only d. total body water plus fat
5
Continuing with the same example, acetaminophen
has a clearance of 5 ml/min/kg, what is its rate
of elimination (mg/min/kg)? a. 715 b. 0.715
6
Continuing with the same example, acetaminophen
has a clearance of 5 ml/min/kg, what is its rate
of elimination (mg/min/kg)? a. 715 b.
0.715 Answer b Kel CL x Cp 5
ml/min/kg x 0.143 mg/L But watch your units!
0.143 mg/L 0.143 mg/ml 5 ml/min/kg x
0.143 mg/ml 0.715 mg/min/kg
7
Continuing with the same example, What is its
t1/2 (min)? a. 0.124 b. 124 Answer t1/2
0.693 x Vd/CL 0.693 x (0.9 L/kg)/(5
ml/min/kg) Again, watch your units 5 ml/min/kg
0.005 L/min/kg t1/2 0.693 x (0.9 L/kg)/(0.005
L/min/kg) 124 min
8
The graph shows the plasma concentration as a
function of time for three different conditions.
Are these conditions a. different doses of
drug b. different rates of elimination c.
different rates of absorption
9
The graph shows the plasma concentration as a
function of time for three different conditions.
Are these conditions a. different doses of
drug b. different rates of elimination c.
different rates of absorption
10
Match the curve to the route of administration.
____ I.M. ____ I.V. ____ Oral ____
Sublingual ____ Extradermal patch ____
Inhalation
11
Match the curve to the route of administration.
__c_ I.M. __a_ I.V. __b_ Oral __a_
Sublingual __c_ Extradermal patch __a_
Inhalation
12
The graph shows the plasma concentration as a
function of time for two different conditions.
Are these conditions a. different doses of
drug b. different rates of elimination c.
different rates of absorption
13
The graph shows the plasma concentration as a
function of time for two different conditions.
Are these conditions a. different doses of
drug b. different rates of elimination c.
different rates of absorption
14
The graph shows the plasma concentration as a
function of time for two different conditions.
Are these conditions a. different doses of
drug b. different rates of elimination c.
different rates of absorption
15
The graph shows the plasma concentration as a
function of time for two different conditions.
Are these conditions a. different doses of
drug b. different rates of elimination c.
different rates of absorption