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PO-67 M. Martinez-Rebollar et al. Objective ... PO-67 M. Martinez-Rebollar et al. 1.46 (1.06;2.02) Calendar year. CD4 cell count. Age ... – PowerPoint PPT presentation

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Title: Presentacin de PowerPoint PO67


1
PO-67 M. Martinez-Rebollar et al.
Objective To identify factors associated with
virological, immunological and clinical outcome
in naïve patients who have initiate HAART from
January 1997 to December 2006.
  • Methods
  • Retrospective cohort study
  • Including all antiretroviral naïve patients who
    have initiate HAART from 1997 to 2006 in a
    tertiary hospital in Barcelona.
  • Evaluate by calendar year (1997-00, 2001-03 and
    2004-06) and CD4 strata (lt200, 201-350 and 350)
  • The demographic and clinical characteristics at
    the initiation of HAART
  • The composition of the antiretroviral regimen
  • CD4 response
  • Clinical outcome (development of new AIDS events
    and/or non-AIDS related mortality) using a
    multivariate analysis.

2
PO-67 M. Martinez-Rebollar et al.
Results Adjusted Hazard Ratio (95CI) of
progression to aids and death
Sex, age, VL at baseline, type of ARVc regimen,
risk factor were also evaluated but not included
in the final model
3
PO-67 M. Martinez-Rebollar et al.
Conclusions
  • In HAART era, the response to initial
    antiretroviral therapy in terms of CD4 rise,
    clinical outcome and survival has gradually and
    significantly improved.
  • But remain significantly worse among older
    patients and late presenters.
  • HAART should be initiated, at least, when CD4
    cell count drop lt 350.

4
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