ION CRAFT Project Presentation

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ION CRAFT Project Presentation

• DELIVERABLE 2

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General Overview

• Title A sequential high throughput ion channel
  screening system for drug discovery in
  neurological and psychiatric disorders
• Acronym ION
• Framework Sixth Framework Programme
• Programme Horizontal Research Activities
  Involving SMEs Co-operative Research
• Contract No. 513190

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ION Consortium (1)

• SMEs
• Newron Pharmaceuticals SpA
• (Coordinator - Italy)
• Multi Channel Systems GmbH
• (Germany)
• SC IT Romania Srl
• (Romania)
• Nikem Research Srl
• (Italy)

• RTD Performers
• University of Debrecen
• (Hungary)
• Università di Firenze
• (Italy)
• Polish Academy of Sciences
• (Poland)
• Istituto Mario Negri
• (Italy)
• Politecnico di Milano
• (Italy)

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ION Consortium (2)
SMALL MEDIUM ENTERPRISES
NWP
NKR
MCS
ITR
ION PROJECT
IRFMN
UD
IFPAN
UNIFI
POLIMI
RESEARCH AND TECHNOLOGICAL DEVELOPMENT PERFORMERS
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Objective of the ION CRAFT Project

• The aim of the ION project is to improve the
  efficiency of drug screening for a specific set
  of neuronal cell targets.
• These targets are ion channels involved in
  important neurological and psychiatric disorders.
• The objective will be approached by
• increasing the efficiency of sequential screening
  by improvingboth the experimental platform and
  the management of the experimental data
• producing intelligent software agents capable of
  an adaptive planning of the experiments
• validating the results by predictive animal
  models.

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ION Project Components

• The ION Project focuses on five main components
• An annotated library covering a large number of
  ion channel targets and a design of chemical
  structures in relation to the most important ion
  channel targets
• IONEP experimental platform
• Experiment Evaluator and Planner (AI Software)
• In Vivo Validation
• IONEP Integrated Pilot.

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ION Project Structure
ION PROJECT
IONEP
EXPERIMENTS PLANNER
LIBRARIES
IN VIVO VALIDATION
ION SYSTEM INTEGRATION
MCS PLATFORM
ION CHANNELS TARGETS
MODELS LIBRARY
VALIDATION OF THE LIBRARIES BY IN VIVO STUDIES
IONEP INTEGRATED PILOT
IONEP VIRTUALIZATION SOFTWARE
CHEMICAL STRUCTURES
EXPERIMENTS EVALUATOR AND PLANNER
IMPROVED DRUG SCREENING PROCESS
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ION Workplan

• The ION workplan is characterized by a focused
  research and development approach.
• The main activity subjects are
• Research on ion channels focused on molecular
  targets suitable for drug screening
• Design of chemical structures in relation to the
  identified ion channel targets
• Development of IONEP experimental platform
• Development of an Experiments Planner
• All the developed components will be integrated
  in the IONEP pilot.

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ION Project Activity Types
ION PROJECT
RESEARCH
TECHNOLOGICAL DEVELOPMENTS
DISSEMINATION
MANAGEMENT
Targets Library
IONEP
Standard Activities
Activities Management
Structures Library
Experiments Planner
ION Web Portal
Risks Management
ION Integration
Business Plan
Project Administration
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ION Project Activity TypesWorkpackages
WP 3
ION PROJECT
RESEARCH
TECHNOLOGICAL DEVELOPMENTS
DISSEMINATION
MANAGEMENT
Targets Library
IONEP
Standard Activities
Activities Management
Structures Library
Experiments Planner
ION Web Portal
Risks Management
ION Integration
Business Plan
Project Administration
WP 1
WP 2
WP 4
WP 5
WP 6
WP 7
WP 8
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Workpackage List
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Workpakage Responsibilities (1)
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Workpakage Responsibilities (2)
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Workpakage Responsibilities (3)
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PERT Diagram
WP 1 Project Management
WP 3 User Requirements
RESEARCH
TECHNOLOGICAL DEVELOPMENTS
WP 4 ION Experimental Platform (IONEP)
WP 5 Development and Validation of the Target
Library
WP 8 Integration and Testing of the ION
Sequential Screening System
WP 7 Development and Validation of Sequential
Screening Software
WP 6 Development and Validation of the Chemical
Structure Library
WP 2 Dissemination of Results and Business Plan
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Workplanning and Timetable
1-24
1-24
1-4
4-12
5-20
9-22
11-24
17-24
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Project Work Organization

• The ION Project organizes the work by
  workpackages.
• A workpackage is a coordinated and consistent
  cluster of activities to be executed in a given
  time period.
• In ION the single activity are called tasks.
• The entire project has been subdivided into 8
  workpackages and 44 tasks.

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WP1Project Management
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WP2Dissemination of Results and Business Plan
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WP3User Requirements
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WP4ION Experimental Platform (IONEP)
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WP5Development and Validation of the Target
Library
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WP6Development and Validation of the Chemical
Structure Library
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WP7Development and Validation of Sequential
Screening Software
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WP8Integration and Testing of ION Sequential
Screening System
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ION CRAFT Budget approved by the EC
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ION Project Management Organization
European Commission
ION Steering Committee
ION Project Manager Carla Caccia - NWP
Quality Review
ION Project Coordinator Patricia Salvati - NWP
WP Leader
WP Leader
WP Leader
WP Leader
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ION Project Steering Committee (PSC)

• The Project Steering Committee members are
• Patricia Salvati (NWP ION Project
  Co-ordinator)
• Carla Caccia (NWP ION Project Manager)
• Karl-Heinz Boven (MCS)
• Gabriele Del Barba (ITR)
• Giulio Massimo Dondio (NKR)
• Miklós Antal (UD)
• Flavio Moroni (UNIFI)
• Krzysztof Wedzony (IFPAN)
• Annamaria Vezzani (IRFMN)
• Giuseppina Gini (POLIMI).

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Project Management Responsibility

• The Overall Project Management will be the
  responsibility of the NWP, the ION Project
  Coordinator.
• NWP, as Project Manager, will put the necessary
  procedures to execute and control in place, and
  together with the partners will operate these
  procedures.
• This is necessary to ensure that the project is
  managed effectively at all times.
• The position of the Project Manager has been
  assigned to NWP which has appointed Mrs. Carla
  Caccia.

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ION Quality Review Committee (QRC)

• The Quality Review Committee members are
• Ruggero Fariello (NWP SMEs Representative
  Chairman)
• Miklós Antal (UD RTDs Representative RTD)
• Gian Giacomo Consalez (Member External to the
  Project)

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Project Scientific Leader

• The Project Scientific Leader is the person
  within the Consortium who has an overall
  understanding and vision of the scientific
  aspects of the project.
• The primary responsibility of the Project
  Scientific Leader will be to assure that
  different workpackages and tasks are
  complementary and that technical interfaces are
  in accordance with the workpackage
  specifications.
• The Project Scientific Leader will be
  responsible for solving inconsistencies or issues
  affecting more than one workpackage and for
  authorising changes to the original
  specifications and procedures in compliance with
  the PMD Change Control Procedure.
• The position of the Project Scientific Leader
  has been assigned to the ION co-ordinator NWP who
  has appointed Mrs. Patricia Salvati.

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Workpackage Management

• Each workpackage will be managed as a
  sub-project.
• The workpackage leader will be put in charge as
  coordinator of all activities within a specific
  workpackage. The project manager will be
  responsible for coordinating workpackage progress
  and for collecting the progress information into
  a monthly project progress report for the Project
  Steering Committee.
• The workpackage leader will be responsible for
  ensuring that the deliverables from its
  workpackage are available accordingly with the
  global project workplan and for achieving the
  necessary levels of quality.

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Project Communication

• ION pull together a transnational group of
  partners doing quite different activities in
  still far apart working contexts
• Effective communication is an essential
  capability required all time during the project
  execution
• ION addresses the issue by establishing two
  communication platforms
• A project intranet supporting a state of the art
  collaborative workspace for the internal project
  requirements
• A web site for dissemination of project results
  and mediaaccess.

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Project Management Contact Point

• Project Manager
• Mrs. Carla Caccia
• Newron Pharmaceuticals SpA
• Project Secretariat
• Mrs. Arianna Baldo
• Newron Pharmaceuticals Spa
• Phone [phone]
• Fax [phone]
• ION PROJECT E-MAIL
• ioncraft_at_newron.com

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Conclusion
ION CRAFT Project