Deposition av partiklar i andningsvgarna

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Deposition av partiklar i andningsvägarna

• Jakob Löndahl1, Joakim Pagels2, Erik Swietlicki1,
  Andreas Massling1
• Elvira Vaclavik3, Christoffer Boman4, Steffen
  Loft3, Mats Bohgard2
• Anders Blomberg5 and Thomas Sandström5
• 1Department of Physics, Lund University, PO Box
  118, SE-221 00, Lund, Sweden
• 2Division of Aerosol Technology (EAT), Lund
  University, PO Box 118, SE-221 00, Lund, Sweden
• 3Department of Environmental and Occupational
  Health, Institute of Public Health, Copenhagen,
  Denmark
• 4Department of Physics, Lund Institute of
  Technology, PO Box 118, SE-221 00, Lund, Sweden
• 5Department of Respiratory Medicine and Allergy,
  University Hospital, SE-901 85, Umeå, Sweden

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John Tyndall(1820-1893)
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Linking Emissions to Health Effects
Lung Deposition
Emission
Exposure
Dose
Health effect
Concentration





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• Factors determining respiratory tract deposition
• exposure concentration
• exposure duration
• inhaled volume
• deposition probability
• paticle properties - size, hygroscopicity
• respiratory tract anatomy
• ventilatory parameters

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Experiemental design

• 29 healthy adults
• 20 men, 9 women
• Age 20-38
• Healthy (lung function tested)
• Four experiments, each 21 minutes
• Oil (DEHS) relax/exercise
• NaCl relax/exercise

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Mean values
Deposited dose Deposition fraction x
Inhaled volume
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Model comparison (ICRP)
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Gender differences
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Intersubject variability (oil, rest)
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Intersubject variability (oil, exercise)
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Intersubject variability (correlation)
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• Conclusion
• Difference in Deposited Dose?

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• Conclusion Deposited Dose?
• Rest/Exercise
• inhaled volume 4 times larger during exercise
• ?4 times higher dose
• Hydrophobic/Hygroscopic
• for 0.1 µm particles, factor 4 difference
• ?4 x 4 16 times higher dose
• Intersubject variability
• factor 3 difference between subjects
• ?4 x 4 x 3 48 times higher dose

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• Biomass and Traffic

DF 0.2
DF gt 0.5
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• Wood smoke

• Relatively modest and ambiguous effects
  determined so far!
• No effects on lung function (FEV1, FVC)
• No increase in exhaled NO
• No increase in inflamatory marker
  cells (bronchoalveolar lavage)
• Increase in GSH, Glutathione ? indicates
  oxidative stress
• Certain morphological changes observed
  in alveolar macrophages

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• Future

Respiratory deposition of Diesel
particles Susceptible subgroups (children,
asthmatics, COPD...) Low temperature of inhaled
air Different air masses ...
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• Tack för uppmärksamheten!

Sponsors
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Accuracy