The Antitumor Immune Response

1
The Antitumor Immune Response
2
Structures of Class I and Class II Major
Histocompatability Complex (MHC) Molecules
With permission from Abbas et al. Cellular and
Molecular Immunology. 1994
3
Pathway of Antigen Presentation by
Antigen-Presenting Cells
4
Interactions of the Antigenic Peptide With the
Major Histocompatability Complex (MHC) Molecule
and the T-Cell Receptor (TCR)
With permission from Garcia et al. Science.
1996274209.
5
Role of Costimulation in T-Cell Activation
6
Effector Mechanisms of Tumor Cell Killing by
Cytotoxic T Cells (CTLs)
7
Direct and Indirect Mechanisms Through Which
Antitumor Antibody Can Mediate Tumor Cell
Killing Directly
8
Survival Curves of ECOG Trial 1684
With permission from Kirkwood et al. J Clin
Oncol. 1996147.
9
Sources of Antigens for Vaccines Stimulating
Cell-Mediated Antitumor Immune Responses
10
Tumor-Associated Antigen-Based Cancer Vaccines
and Roles of Antigen-Presenting Cells (APCs) in
Antigen Uptake and Presentation
11
Scanning Elecron Micrographs of Dendritic Cells,
Indicating Some of the Surface Changes Occurring
With Maturation
Courtesy of Walter Storkus and Robbie Mailliard,
University of Pittsburgh School of Medicine.
12
Antibody Structure and Production of Bispecific
and Humanized Monoclonal Antibodies