BDI confidential presentation

1
Marie Curie TOK project CardiChip Jimmy
Bakker Biomedical Diagnostics Institute, DCU Åmic
AB, Uppsala, Sweden
2
CardiChip

• Collaborative research project between Åmic AB of
  Uppsala Sweden and the Biomedical Diagnostic
  Institute (BDI) based at Dublin City University,
  Dublin, Ireland.
• Secondment of two researchers from Åmic AB to
  work at the BDI to develop a novel low cost
  biochip that can provide a diagnostic and
  prognostic indication of the risk factors of
  cardiovascular disease (CVD).
• Researchers, non-academic personnel and
  affiliates from both participant organisations
  will assist in the transfer of knowledge through
  regular interactions, visits and workshops.

3
Cardiovascular Disease

• Critical Problem
• Accounts for 38 of all deaths (2004)
• Primary Prevention
• Implementation of preventive
• strategies before CVD is clinically manifested
• Secondary Prevention
• Identifying and treating people at high risk of
  developing CVD

4
Cardiovascular Risk Biochip

• BDI Concept
• Simple, low cost, monitoring of early cardiac
  risk markers
• Risk stratification primary/secondary prevention
• Early intervention lifestyle changes
• Better patient outcomes health and cost benefits
• Cardichip
• Multiplexed detection of cardiac protein markers
• Åmic open lateral flow (OLF) platform
• Supercritical angle fluorescence (SAF) detection
  

5
Objectives

• To develop new state of the art skills and
  expertise that would otherwise be inaccessible.
• The develop novel diagnostic devices that will
  directly affect the quality of peoples lives
• To build real and sustainable partnership between
  Amic and BDI to access world-leading
  complementary expertise
• To train high quality researchers in
  multi-disciplinary skill sets

6
CVD RISK CHIP
Nanoparticle labels
Engineered antibodies and oriented attachment
Sample clean-up/cell filtration
Surface functionalisation
Sample application zone
Reagent zones
Microfluidic architecture
Reservoir
Immobilised antibodies
Detection zones
Open lateral flow platform
7
Wireless communication
Digital readout of result
Detection
8
Results so far

• Reader developed and tested
• Chips optimized for readout in new reader
• New surface chemistry developed
• Antibodies developed for projected analytes
• Ongoing work on integrating all parts

9
Transfer of knowledge

• Researchers and supervisors travel between host
  institution and industrial partner for mutual
  knowledge transfer
• Annual Transfer Of Knowledge mini conference
  involving all involved researchers

10
Conclusions

• Very interesting project
• Great opportunity to look over the border
• Interesting symbiosis between academia and
  industry
• Clear path to commercialization