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Objectives from Integrative Lit review

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Distinguish odds ratio, relative risk, sensitivity, and specificity ... If few, reasonable alternatives should be evaluated on their merits ... – PowerPoint PPT presentation

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Title: Objectives from Integrative Lit review


1
Objectives from Integrative Lit review
  • Know what kinds of research questions can an
    integrative literature review answer.
  • Describe 4 reasons meta-analyses might be lame
    and 3 reasons they might not be lame.
  • Be aware of the judgment calls and possible
    effects of those judgment calls on the results of
    narrative and meta-analytic reviews (note the
    chapter is largely about the decisions reviewers
    make)

2
Interpreting Research Results
  • February 28

3
Question
  • Do we discover the truth or construct it?

4
Objectives
  • Understand threats to valid inferences
  • Distinguish odds ratio, relative risk,
    sensitivity, and specificity
  • Consider chance as an alternative hypothesis
  • Know possible sources of Type II error
  • Describe the self-efficacy paradox, its relation
    to the changing signs of the SE-performance
    relationship, and its possible resolution

5
Threats to Valid Inferences
  • Fallacy of the mean
  • Group score does not apply to all in the group
  • Omnibus test interpreted as directional and
    supportive
  • Making ratio conclusions with less than ratio
    data
  • E.g., attitude changed twice as much
  • E.g., multiplicative element of expectancy X
    valence theories
  • See below

6
Odds Ratio
  • Index of strength of relationship (also called
    relative odds, which is not the same as relative
    risk)
  • OR ad/bc
  • RR a(b d)/b(a c) - If
    disease is rare, RR ? OR

7
Berksons Fallacy
  • Danger is that these indices are sensitive to
    sampling bias.
  • If sample is more likely diseased and exposure
    more likely to lead to disease, a is inflated
    relative to the population and hence odds ratio
    is inflated
  • Is relative risk?

8
Sensitivity and Specificity
  • Sensitivity is the ability to the
    predictor/screen/test to give a positive finding
    when the person is truly positive
  • Specificity is the ability of the
    predictor/screen/test to give a negative finding
    when the person is truly negative

9
Screening
Validity
Truth
Sensitivity a/(a c)
a
Diseased
c
Not diseased
b
Specificity d/(b d)
d
Predictor(s)
10
Chance as an Alternative Hypothesis
  • Validity is a question the interpretations of
    results
  • Your interpretation(s) is(are) assessed against
    others
  • Number of others with reasonable possibility
  • Possibility of each
  • If few, reasonable alternatives should be
    evaluated on their merits
  • Statistics allows us to assess the probability
    that chance is an explanation if experimental
    hypothesis supported
  • Or the probability that chance is not the
    explanation if null supported

11
Question
  • Can/should we interpret a null finding as one of
    no relationship?

12
Possible Source of Type II
13
Other issues
  • Stronger theories with point estimates (instead
    of simply, not zero)
  • One persons bias is anothers theoretical
    perspective
  • Presentation
  • Sample presentation
  • Example of interpretation issues
  • Example of bias/theoretical perspective
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