INTERxVENTUSA

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INTERxVENTUSA

• LEADING DISEASE PREVENTION INTO THE 21ST CENTURY

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INTERXVENT

• We have spent many years (1995 - present)
  developing, testing, and, most recently,
  implementing evidence-based lifestyle management
  and chronic disease risk reduction programs.
• Concurrently, we have developed and tested the
  systems, tools, technology, and protocols to
  facilitate the widespread implementation of these
  programs.

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Key Milestones

• Developed and Brought to Market 13 Products
• Over 40 Publications re Clinical Trials
• Licensees Include Mainstream Medical Leaders in
  U.S. and Canada
• Service Provision to Fortune 500 Companies
• Endorsement by and Strategic Relationships with
  Professional Organizations
• Strategic Relationships with National Health Care
  Providers and Others

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Health Plans
Employers
National Organizations
Licensees
INTERxVENT Command and Control ? IT ?
Systems ? Tools ? Protocols
Pharma/Other Companies
Physicians/ Providers
Rehab Centers
Mentors
Call Centers/ Virtual Call Centers
Consumers/ Patients
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INTERxVENTUSA Partial Listing of Contractual
Agreements

• Savannah, GA
• St. Josephs/Candler Health System
• Atlanta, GA
• Emory Healthcare
• Boca Raton, FL
• Boca Raton Community Hospital
• Teaneck, NJ
• Holy Name Hospital
• Ann Arbor, MI
• University of Michigan
• Lincoln, NE
• Bryan LGH Medical Center

• Tallahassee, FL
• Tallahassee Memorial HealthCare
• Hattiesburg, MS
• Forrest General Hospital
• Detroit, MI
• William Beaumont Hospital
• Toledo, OH
• Medical College of Ohio
• Morehead, KY
• St. Claires Medical Center
• Wilmington, NC
• New Hanover Regional Medical Center

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INTERxVENTUSA Partial Listing of Contractual
Agreements
(contd)

• Kalispell, MT
• The Summit at Kalispell Regional Medical Center
• Ottawa, Canada
• University of Ottawa Heart Institute
• Los Angeles, CA
• Cedars-Sinai Medical Center
• Edmonton, Canada
• University of Alberta
• Mobile, AL
• Providence Hospital

• Dallas-Fort Worth, TX
• Presbyterian Hospital-Dallas
• Presbyterian Hospital-Plano
• Harris-Methodist Hospital-Fort Worth
• Harris-Methodist Hospital-HEB
• Chattanooga, TN
• Memorial Hospital
• Memorial North Park Hospital
• Norwalk, OH
• North Central CareNet
• Seattle, WA
• Swedish Health System

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Key Published Research

• Over 40 Published Scientific Abstracts From
  National and International Scientific Meetings
• Six Key Scientific Manuscripts
• 1. Comparison of single versus multiple lifestyle
  interventions Are the antihypertensive effects
  of exercise training and diet-induced weight loss
  additive? Am J Cardiol 199779763-767.
• 2. Comprehensive cardiovascular disease risk
  reduction in a cardiac rehabilitation setting.
  Am J Cardiol 199780(8B)69H-73H.
• 3. Comprehensive cardiovascular disease risk
  reduction in the clinical setting. Coronary
  Artery Disease 1998 9731-735.
• 4. Innovative approaches to comprehensive
  cardiovascular disease risk reduction in clinical
  and community-based settings. Current
  Atherosclerosis Reports 2001 3498-506.
• 5. Effects of a contemporary, exercise-based
  rehabilitation and cardiovascular risk reduction
  program on coronary patients with abnormal
  baseline risk factors. CHEST 2002 122338-343.
• 6. Effectiveness of 3 models for comprehensive
  cardiovascular disease risk reduction. Am J
  Cardiol 2002891263-1268.

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INTERxVENTUSA Key Research Findings
Significant improvements in multiple CVD risk
factors in

• Patients with metabolic syndrome
• Overweight/obese
• Patients with prediabetes
• Patients with hypertriglyceridemia
• Patients with arthritis
• Participants in rural and urban communities
• Educated and less-well-educated participants

• Males and females
• Caucasians and African Americans
• Healthy persons
• Patients with CAD
• Patients with diabetes mellitus
• Patients with previous stroke, carotid artery
  disease and/or TIA
• Patients with hypertension

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Change in Body Weight in Obese
Participants(INTERxVENT 1- Year Program
Participation Data)
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INTERxVENTUSA Key Research Findings
(contd)

• Clinically relevant and reproducible improvements
  in multiple CVD risk factors when administered by
  licensee institutions
• Improvements in all eight SF-36 domains
  (indicators of well-being)
• INTERxVENT Program is at least as effective as a
  Phase 2 cardiac rehabilitation program and a
  physician supervised/nurse case managed program
  in CAD patients despite a substantially lower
  cost and greater accessibility

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INTERxVENTUSA Key Research Findings
(contd)

• INTERxVENT Program is at least as effective when
  administered remotely from a call center using
  the telephone and the Internet (INTERxVENTOn
  Call) as compared with onsite delivery
  (INTERxVENTLive)
• Reductions in average healthcare claims in
  employees who participate in the INTERxVENT
  Program as compared with employees who do not
  participate

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INTERxVENT Core Products

• One-on-One Counseling (Mentor Assisted)
• INTERxVENTLive - face-to-face counseling
• INTERxVENTOn Call - counseling via
  telephone/Internet
• INTERxVENTCR - delivery during cardiac
  rehabilitation
• INTERxVENTDiabetes - diabetes self-management
  program
• Self-Help (Non-mentor Assisted)
• INTERxVENTGetting Started - introductory
  awareness/education program
• INTERxVENTWeight Management, Quit Smoking(etc.)
  -12-week programs
• INTERxVENT_at_Home - comprehensive one-year
  lifestyle intervention/disease management program

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WHAT MAKES INTERxVENT LIFESTYLE
MANAGEMENT/SELF-CARE PROGRAMS UNIQUE AND
SUCCESSFUL?
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WHAT MAKES INTERxVENT LIFESTYLE
MANAGEMENT/SELF-CARE PROGRAMS UNIQUE AND
SUCCESSFUL? (contd)
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Rationale For INTERXVENT MD Network

• MDs are enthusiastic about prevention. However,
  MDs generally do not have the time, resources, or
  infrastructure for the provision of comprehensive
  preventive services (especially lifestyle
  management). MDs are generally not compensated
  for lifestyle management services.
• INTERxVENT MD Network allows MDs to provide their
  patients with a credible, affordable,
  evidence-based program without burdening them or
  their staff.

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INTERxVENT Program Steps

• Incorporates All Essential Components of a
  Comprehensive Chronic Disease Risk Reduction
  Program
• Identification of At-Risk Individuals
• Initial Evaluation (Medical History / Health
  Habits Questionnaire and Evaluation)
• Goal Setting (Guideline-Based for BP, Lipids,
  Physical Activity, Nutrition, Weight, Blood
  Glucose, Smoking etc.)

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INTERxVENT Program Steps
(contd)

• Action Plan Formulation (Guideline-Based)
• Lifestyle Management (Including Nutrition,
  Weight Management, Exercise, Smoking Cessation,
  Stress Management)
• Disease Management Issues (Including Obesity,
  Hyperlipidemia, Hypertension, Diabetes, Stroke,
  CAD)
• Medication Changes/New Medications (Including
  Lipid Lowering, Antihypertensive, Antidiabetic,
  Beta Blockers, ACE inhibitors/ARBs and
  Aspirin/Antiplatelet Agents)
• Physician and Other Referrals (MD Network)

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INTERxVENT Program Steps
(contd)

• Action Plan Implementation
• Including Exercise Training, Correct Nutrition,
  Dietary Supplements, Weight Management, Smoking
  Cessation, and Stress Management
• One-on-One Coaching/Mentoring May Be Conducted
  On-Site at INTERxVENT Delivery Site or Delivered
  Remotely Via Phone/Internet
• Uses State-of-the-Art Behavior Change Techniques
  and Guidance from Computerized System Counseling
  Conducted Using Behavioral Interventions Derived
  From Several Well Established Models (e.g. Social
  Learning Theory, Stages of Change Model, Single
  Concept Learning Theory)

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INTERxVENT Program Steps
(contd)

• Follow-up Evaluation and Progress Reports
• Evaluation in Person, by Phone, or Internet
• Computer Generated Progress Reports
• Documents Program Compliance, Progress in
  Achieving Goals, Need for Referrals (Including
  for New Medications/Medication Changes), Revises
  Goals (If Needed)
• Compliance Enhancement/Tracking
• Aggregate Outcomes Assessment

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INTERxVENT LIFESTYLE MANAGEMENT AND SELF-CARE
PROGRAMS THE NEXT GENERATION OF DISEASE
MANAGEMENT

• Proven effective in randomized clinical trials
• Over 40 published scientific manuscripts and
  abstracts documenting benefits in clinical
  indicators, well-being, and health care
  expenditures in diverse populations
• Integration with each participants regular
  medical care, with widespread acceptance by
  mainstream medical leaders
• Used by Emory University, University of Michigan,
  Cedars-Sinai Medical Center, William Beaumont
  Hospital, University of Ottawa, and other
  prestigious institutions
• Affordable and applicable across the entire
  health continuum
• Applicable to keeping healthy people healthy as
  well as to persons with multiple chronic
  conditions

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INTERxVENT LIFESTYLE MANAGEMENT AND SELF-CARE
PROGRAMS THE NEXT GENERATION OF DISEASE
MANAGEMENT (cont)

• Go beyond awareness/education to actual
  intervention
• Evidence-based, guided implementation of
  individualized and comprehensive
  exercise/physical activity, nutrition, weight
  management, smoking cessation, stress management,
  and other behavior change and self care
  programs
• Combines high tech and high touch
  interventions
• Can be administered in person, via telephone
  and/or Internet
• Participant-centric interventions
• Based on each individuals readiness to change,
  clinical circumstances, personal preferences, and
  available resources
• Continuously monitors and enhances individual and
  aggregate compliance and outcomes
• Web-enabled computerized participant management,
  tracking, reporting, outcomes, etc. database