Weed, Pot, Reefer, Cannabis

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Weed, Pot, Reefer, Cannabis

• Anybody want to get a pizza?

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Introduction

• Cannabis sativia
• May also be other species
• One type is actually very low in THC and quite
  useful for cloth, rope, paper, etc.
• Speaking of THC, it is the active ingredient in
  pot
• Delta-9-Tetrahdrocannabinol
• Also Delta-8- Tetrahdrocannabinol
• Delta 9 is the biggie though

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Administration

• You can
• Eat it
• Cookies, brownies
• Smoke it
• Joints, bongs, onehits
• Hash and hah oil/weed oil
• Drink it
• Tea

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Roll Your Own

• Recently some synthetics have been developed
• Dont work as well as taking a hit off a Doobie
• synhexyl
• nabilone
• Used in chemo treatment
• dronabinol
• (Marinol)

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A little History

• Initially spread by the Scythians
• Where do you think the word Assassin comes from?
• Chinese liked it, then they got the munchies and
  ordered Chinese food
• 6000 years ago
• Got to India
• Ganja and bhang

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More History

• In Europe and North America it was used for rope,
  cloth etc, intoxicating effects were not noticed
  for years.
• George Washington grew Hemp!
• Gauthiers Le Club de Hachichins
• Big as a cash crop in the States
• (Still is ?)
• 1937 Marijuana Tax Act
• 1970 Became Illegal in the US, Canada.

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Recent History

• Medical Marijuana laws in US and Canada
• Feds actually growing weed in Flin Flon, MB
• Netherlands
• Pot was almost legal last year!

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Absorption, Distribution, Etc..

• VERY lipid soluble
• Very slowly absorbed when administered orally
• 3x the dose than for smoked pot
• Much longer lasting high
• Smoking works way better
• 50 of THC goes to lungs
• Then to your brain

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Absorption etc

• Many of the compounds created during burning are
  also psychoactive
• Metabolized in liver mostly
• Other places too
• Lungs if smoked
• Intestines if eaten
• Metabolites are active
• Cannabidiol blocks metabolism of THC

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Neuropharmacology

• Radioactive Levonantradol
• (syntehtic cannabinoid)
• Group in the next lab found a gene that coded for
  a receptor site
• The maps matched!
• Science is cool

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So, where are the receptors for THC?

• Cortex
• Hippocampus
• Cerebellum
• Basal ganglia
• Spinal cord
• Brainstem
• Hypothalamus
• Spleen!

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Effects

• Bloodshot eyes
• Droopy eyes
• The drys
• The munchies
• Increased heart rate
• Reduction of pressure of fluid in eye!

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More effects

• Stops nausea
• Anticonvulsant
• Antibiotic
• Sleep effects
• Everything is way funny
• Mood changes

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Even more effects

• Analgesic
• Memory
• Recall not recognition
• STM
• HP effect?
• Attentional effects

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Hey man, this weed has lots of effects.

• DONT DRIVE A CAR
• Biphasic effects on SMA
• Taming effect
• Timing effects
• Crystal (2003)
• Reverse Tolerance?
• Mild Withdrawal

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You wanna get high?

• Other species dont do it
• Titration
• Usually smoked in groups
• Most users are casual users
• ritualistic

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Bad stuff

• Violence?
• Makes crazy people go nuts
• Freak outs
• Gateway drug?
• Reproductive effects?
• Cancer, lung disease?
• Probably, but how much is smoked?