www.pasg.org.uk

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Future Opportunities for the Pharma-Academic
Interface
Pharmaceutical Analytical Sciences Group Chair,
PASG
Pharmaceutical Analytical Sciences Group
Analytical Research Forum 2008
www.pasg.org.uk
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Our objectives for today

• To begin a dialogue on future skills needs in
  pharmaceutical analytical science
• To highlight the increasing need for innovation
• To raise awareness of the role PASG can play in
  bridging the gap between Phama and Academia

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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What is the PASG?

• The Pharmaceutical Analytical Sciences Group
  (PASG) is a forum for analytical scientists
  engaged in the management and practice of
  analytical science in chemistry and pharmacy
  disciplines within research operating in the UK

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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What is our remit?

• The PASG exists to
• Support communication of Pharmaceutical Analysis
  issues between UK based RD
• Promote the image and profession of
  pharmaceutical analysis
• To act as a single voice from member companies to
  regulatory agencies
• To work with UK Academia to further innovation
  in analytical science and the education of future
  analysts

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Member Companies

• Merck Sharp Dohme
• 3M Health Care
• Lilly
• Abbott Laboratories Limited
• Bristol Myers Squibb
• Sanofi Aventis
• GlaxoSmithKline
• Wyeth Research
• AstraZeneca
• Pfizer
• Associate Members

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Challenges to UK Pharmaceutical Analysis

• Recruitment of core specialist skills
• Increasing complexity of drug substances, drug
  products the drug development process
• Tighter regulations e.g. Potential Genotoxic
  Impurities
• Generics competition
• Tighter budgets increased productivity
• Low cost countries commoditisation of routine
  Pharma RD
• Need for greater innovation in analytical science

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Opportunities for Pharmaceutical Analysis in the
UK

• To understand and utilise the expertise and
  research areas in the UK now and in the future
• Cross industry/academia partnerships to solve
  common problems
• To work together to train our scientists to
  innovate for the future challenges
• To take advantage of Quality by Design the
  changing regulatory framework
• To work together to influence funding bodies for
  analytical science to our mutual benefit

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Previous research areas

• Stability
• Process Analytical Chemistry
• Academic Liaison
• Biopharm
• Parametric release
• Automation
• Potential Genotoxic Impurities
• PAT/NIR
• Sonics
• Nuclear Quadrupole Resonance (NQR)

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Future research areas

• Novel analytical science faster, more sensitive
  more efficient
• Biologics (analysis of mabs, RNAi etc)
• Green chemistry
• Predictive modelling (e.g. stability,
  separations)
• Imaging
• Information processing
• Supporting the Quality by Design paradigm
• Analysis for novel delivery systems

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Training and Development

• The future skills for our scientists
• Good core scientific knowledge
• Innovation/Creativity
• Knowledge understanding
• Business awareness
• Leadership communication skills
• Student placements
• Placements of academics in industry
• Industry experts to speak at academic workshops
• Academic presentations at PASG symposia

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Recent Academic Presentations to PASG

• Professor Pat Sandra, University of Ghent State
  of the art in Separation Sciences for
  Pharmaceutical Analysis.
• Prof. A.P. de Silva, Queen's University of
  Belfast 2007 A Small Space Odyssey with
  luminescent Molecules
• Monica Dolci, Loughborough University LC method
  screening for the separation of surfactants
  employed as pharmaceutical excipients
• Dr. Alex Drake, Kings College London Multi-mode
  Optical Spectroscopy
• Dr. Frederick Lynen, University of Ghent High
  Efficiency Semi-preparative Liquid Chromatography
  at Elevated Temperatures

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group
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Next steps

• We would like to
• Hear your ideas on ways forward for UK
  Pharmaceutical Analysis
• See you present at a future PASG symposium
• Discuss ideas for future collaboration
• Contact the PASG via the website
• www.pasg.org.uk

www.pasg.org.uk
Pharmaceutical Analytical Sciences Group