LTG 1: Multimedia Theme Activities

1
LTG 1 Multimedia Theme Activities

• Site characterization analytical methods,
  statistical methods and sample collection
• Analytical method development
• Mining monitoring and remediation
• Asbestos health effects
• Technical support

2
ProUCL 4.0 Statistical Software Package

• Background
• Exposure assessment and cleanup decisions are
  often made based upon the statistical evaluation
  of the mean concentrations of the contaminants
• PROBLEM
• Nondetects (NDs) are inevitable in most
  environmental data sets.
• Defensible methods to estimate exposure point
  concentrations to verify clean-up has been
  obtained to determine background threshold values
  (e.g., site vs. background) to calculate
  not-to-exceed values.
• APPROACH - software package developed that
  follows EPA procedures and guidance documents
• IMPACT
• Software program has been downloaded over 1100
  times
• Released on June 14, 2007
• Use based on returned registration forms
• Software program is in use by private industry,
  consultants, states, academia, and federal
  government agencies as well as International
  users

3
Advances in Analytical Techniques Involving
Separations and Mass Spectrometry

• Goal Improve the analysis and detection of
  trace analytes in environmental samples that lead
  to improved methods and findings for the Agency
• Areas include capillary liquid chromatography,
  high resolution mass spectrometry (HRMS),
  electron capture negative ion mass spectrometry
  (EC NIMS), and gas chromatography negative ion
  mass spectrometry (GC NIMS).
• Significant Products
• Direct Analysis in Real Time/Time-of-Flight Mass
  Spectrometry
• DART/TOFMS being used and developed for rapid
  screening of field samples with analytical times
  in minutes with no sample preparation.
• Determination of organotins by micro-liquid
  chromatography-electrospray ion trap mass
  spectrometry
• SW-846 Method 8323 usage has been expanded and
  has led to addition of organotins as a drinking
  water contaminant
• GC/NIMS Protocol for Method 8081a Analytes - a
  new SW-846 Method 8276
• Office of Solid Waste wanted to identify
  toxaphene and its congeners
• Effort supported Office of Inspector General
  concerns

4
Immunoaffinity Sample Preparation Methods

• APM 391 (2007)
• Research Question
• Develop and test immunoaffinity (IA) sample
  preparation methods for the effective and
  efficient separation and purification of
  environmental contaminants from sample media
• Why is this research important?
• Provides cost-effective sample preparation for
  quantifying trace levels of contaminants in
  complex matrices.
• Research Approach
• Specific antibodies are immobilized onto a solid
  support forming an IA column
• Columns will be developed based on Van Emon
  et.al., 2007, (CRC press)
• Column performance is tested with real-world
  samples and compared to liquid-liquid,
  accelerated solvent, or solid-phase extraction
  methods
• IA-purified extracts analyzed by both GC/MS and
  ELISA
• Data comparison (e.g., efficiency,
  reproducibility, etc)
• Who will use this research?
• Analysts supporting monitoring for Regions
  Program Offices

5
Immunoaffinity Sample Preparation Methods

• Progress
• Developed sol-gel based IA purification for
  pyrethroids in environmental and dietary samples
  (Kaware, Van Emon, et al., J, Agric. Food Chem.
  2006, 54, 6482-6492.)
• Developed and evaluated IA chromatography column
  for atrazine in environmental and dietary samples
  (Chuang, Van Emon, et al., Analytica Chimica
  Acta., 2007, 58332-39.)
• Evaluated various lots of EPA and commercial
  co-planar PCB antibodies and evaluated IA methods
  for co-planar PCBs
• Evaluating EPA antibodies for PCBs in a sol-gel
  based IA purification approach (on-going study)
• Future Work
• Deliver the internal report (APM 391) on
  immunoaffinity sample preparations in
  September 2007
• Extend research approach to dioxins and furans

6
Mining- Engineering Tech Support Center

• Provided assistance on 32 mine sites in FY 07 and
  FY 08 (about 25 of total assistance)
• Planned or participated in 16 demonstration or
  pilot treatment projects
• Over 20 joint publications and conference
  proceedings articles
• Began ORD pilot on remote data collection at Ten
  Mile site
• Major projects in 7 Regions solvent vapor
  extraction, solidification/stabilization, mine
  treatment, bioremediation
• Biochemical reactor demonstration comparing
  different substrates for mine-influenced water
  (MIW) treatment

7
Luttrell Biochemical Reactor

• Field scale demonstration used to treat leachate
  from mine waste repository
• Site Record of Decision cites passive biological
  treatment as selected remedy
• Demo meeting most WQ criteria Standards
• Longevity issue a concern of State Reactor is
  6 yrs as a treatment cell
• Currently used as pre-treatment saving Region
  25 K / year on treatment costs

8
Looking Ahead

• Draft MOU on MIW technology cooperation
  development with USFS BLM
• CRADA with Freeport-McMoran, Inc. to develop MIW
  treatment technologies
• MOU with Doe Run Mining Company
• Planning with Region 8 for 2 MIW demonstrations
  this summer

9
Libby Amphibole Toxicology NHEERL Research
Components

• Region 8 request in Jan. 07 cost share
• In vitro dissolution and toxicity
• In vivo intratracheal toxicity
• In vivo inhalation toxicity
• Dosimetry
• Autoimmune disease
• Cardiovascular toxicity

10
What Asbestos Samples will NHEERL Study?

• Libby Amphibole
• Highly characterized sample from year 2000
  collection
• Sample collected in 2007 enough for studies
  subchronic and NTP 2-year chronic inhalation
  study
• NHEERL Committed to study 2 other site-specific
  samples
• Swift Creek (Region X) chrysotile
• Rome, OR (Region X) erionite
• Control asbestos samples
• Positive Control UICC amosite
• Negative Control wollastonite

11
Asbestos Fiber Exposure Research

• Goal The goal of this research is to develop a
  framework for modeling asbestos and related fiber
  concentrations in the breathing zone from soils
  and indoor surfaces.
• The Releasable Asbestos Field Sampler (RAFS) has
  been developed to obtain asbestos and related
  fiber releasability data from soil and indoor
  materials (such as carpet) for calculation of
  emission factors
• Validation Obtain asbestos and related fiber
  releasability data from soil and carpet for
  calculation of emission factors. These data will
  be obtained from existing activity-based sampling
  (ABS) data, generation of ABS data, and from any
  instrument tests i.e., the RAFS device.
• Develop empirical asbestos and related fibers
  emission factors and airborne concentration
  distributions using matrix, environmental, and
  activity conditions as independent parameters.
• Develop aerosol physics and fluid dynamics based
  mass balance models to predict height dependent
  breathing zone concentrations.
• Field studies planned in Regions 8 and 10

12
ORD Technical Support Centers

• Monitoring and Site Characterization 44 major
  and 430 short term requests
• Engineering and Treatment 500 requests
• Ground Water 77 requests
• Superfund Health Risk 375 requests, 330
  provisional toxicity values
• Center for Exposure Assessment Modeling 8400
  models downloaded
• Center for Subsurface Modeling Support 12,000
  models downloaded, 375 requests
• Environmental Photographic Interpretation Center
  90 projects training
• Ecological Risk Assessment 6 active projects
• Superfund Technical Liaisons at each region

13
Engineering TSC Technologies Evaluated
14
Ground Water TSC Technologies/Issues Reviewed

• ZVI- PRB
• Nano ZVI
• MNA of Inorganics
• Geochemistry
• Pump and treat
• Hydrogen release
• compounds
• National Remedy Review
• Board Reviews

• DNAPLs
• ISCO
• Metals
• Slug tests
• MNA
• Bioremediation
• Ground water modeling

15
Training Provided in FY06and 07
Capture Zone Analysis for Pump and Treat Systems
Regions 1 and 7 Workshop on Monitored Natural
Attenuation of Inorganic Contaminants in Ground
Water Regions 1, 4, 5, and 8
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Documents Being Finalized

• A Systematic Approach for Evaluation of
  Capture Zone
• at Pump and Treat System
• Measurement of Field Parameters in Ground
  Water
• Sampling
• Uncertainty Associated with Calculation of
  Ground-
• Water Remediation Timeframes
• MNA for Inorganics
• Assessment and Delineation of DNAPL at
  Hazardous
• Waste Sites