NEW SUBSTANCE USE RESEARCH ISSUES

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NEW SUBSTANCE USE RESEARCH ISSUES

• SOCIAL NETWORK INTERVENTIONS , OPINION LEADERS,
  RESPONDANT DRIVEN SAMPLING
• INTEGRATION OF BUPHENORPHINE INTO PREVENTIVE
  INTERVENTIONS FOR IDU
• INTERVENTIONS FOR STIMULANT USERS, COCAINE AND
  METAPHETAMINES, E.G. RECEPTOR BINDERS

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Microbicides Need for woman-controlled barrier
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TYPES OF MICROBICIDES

• MECHANISM OF ACTION EXAMPLES
• 1. SURFACTANTS NONOXYNYL-9
• BELALKONIUM CHLORIDE
• CHLORHEXIDINE
• C 31-G
• 2. ACID-BUFFERING AGENTS BUFFERGEL
• ACI-GEL
• 3. INHIBITORS OF VIRAL ENTRY CARAGEENAN
• PRO2000
• SOLUBLE CD4
• 4. INHIBITORS OF HIV REPLICATION PMPA
• FUSION INHIBITORS
• INTEGRASE INHIBITORS
• 5. NATURAL PRODUCTS LACTOBACILLUS
  SUPPOSITORY
• CYANOVIRIN

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Microbicides

• Spermicides (N-9) have not worked to prevent HIV
  transmission, probably due to genital
  inflammation
• Other compounds are highly promising and are less
  toxic
• Multicenter trials are needed with public sector
  support
• Products that both permit and prevent pregnancy
  are needed
• HPTN 035? Phase II and III, four-arm trial of two
  innovative microbicides (BufferGel and PRO2000
  0.5)
• HPTN 049/050? Phase I safety/tolerance studies of
  cellulose sulfate and PMPA in HIV and HIV-
  persons

BACKGROUND
HPTN HAS DEVELOPED
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