Human Genetic Disorders

1
Human Genetic Disorders

• And Pedigrees

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Human Genetic Disorders

• Cystic Fibrosis disorder which the body
  produces thick mucus in the lungs and intestines.
  Caused by a recessive allele.
• Sickle-Cell Disease affects hemoglobin which
  carries oxygen in the blood. Sickle-cells
  cause clogging of the blood. A co-dominant
  Allele.

3
Genetic Disorders Continued

• Hemophilia sex-linked disorder where a persons
  blood clots very slowly or not at all. People
  with disease do not produce the protein needed
  for clotting. Caused by recessive allele on X
  chromosome.

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Pedigrees

• Geneticists (someone who studies genetics) uses
  a pedigree to trace the inheritance of traits in
  humans.
• It is a chart or family tree that tracks which
  members of a family have a particular trait.

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Pedigree for Albinism
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Notation on the Pedigree

• A circle represents a female.
• A square represents a male.
• A completely shaded square or circle indicates
  the person has the trait.
• A not shaded shape indicates that a person
  neither has the trait or is a carrier.
• A half-shaded shape indicates that a person is a
  carrier.

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More on pedigrees.

• Square is male, circle is female, shaded has
  the trait, unshaded doesnt. Half shaded
  carrier.

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Queen Victorias Family and Hemophilia
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Activity Family Puzzle

• Page 156 in your text.
• You will make a pedigree for cystic fibrosis
  within a family.
• Use proper symbols.
• Read directions carefully.
• Remember for a person to have cystic fibrosis
  they must have two recessive genes. A carrier
  has one recessive gene.