Marijuana and Cannabinoids

1
Marijuana and Cannabinoids

• History
• Pharmacology
• Mechanisms
• Effects
• Long-term Use

2
History

• Hemp
• Forms
• Marijuana
• Sinsemilla
• Hashish

3
Pharmacology

• THC
• Absorption
• Metabolism
• Half-life
• Fat stores

4
Mechanisms

• Receptors
• CB1
• Metabotropic
• Expression pattern
• CB2
• Endocannabinoids
• Anandamide
• 2-AG
• Deactivation
• RETROGRADE MESSENGERS

5
Behavioral and Physiological Effects

• Low Doses - Behavioral
• Buzz
• High
• Being stoned
• Come-down
• Low Doses Physiological
• Blood flow to skin
• HR increase
• Munchies

6
Behavioral and Physiological Effects

• Cognitive effects
• Thinking
• Speech
• Memory
• Locomotor effects
• Reinforcement
• Mesolimbic dopamine

7
Abuse and Chronic Exposure

• Prevalence/Incidence
• Tolerance
• Dependence/Withdrawal
• Symptoms
• Treatment

8
Abuse and Chronic Exposure

• Health Effects
• Overdose?
• Lungs
• Immune system effects
• Reproductive system effects