Antimanic Agents: Teratogenic Risk

1
Antimanic Agents Teratogenic Risk

• Classification Category
• Lithium D
• Valproic acid D
• Carbamazepine C
• Lamotrigine C
• Haloperidol C
• Chlorpromazine C
• Aripiprazole C
• Clozapine B
• Quetiapine C
• Risperidone C
• Olanzapine C
• Ziprasidone C
• Clonazepam C

• The FDA has derived a system of pregnancy
  categories based on the degree to which
  available information has ruled out risk to the
  fetus balanced against the drugs potential
  benefits to the patient
• A controlled studies show no risk
• B no evidence of risk in humans
• C risk cannot be ruled out
• D positive evidence of risk
• X contraindicated in pregnancy

Iqbal MM et al. South Med J. 200194304-322. Yonk
ers KA et al. Am J Psychiatry. 2004161608-620