CardioNet, Inc. Company Proprietary 1

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CardioNet MCOT vs. LOOP Clinical Trial
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CardioNet vs. LOOP Clinical Trial Protocol

• Title The Diagnosis of Cardiac Arrhythmias A
  Prospective, Multi-Center, Randomized Study
  Comparing Mobile Cardiac Outpatient Telemetry
  versus Standard LOOP Event Monitoring
• Principal Investigator Steven A. Rothman,
  Mainline Health Center
• Study Design 17 center, 300 patient randomized
  study to compare the relative value of the
  CardioNet Mobile Cardiac Outpatient Telemetry
  (MCOT) system with a patient activated external
  looping event monitor (LOOP) for symptoms
  (palpitations, syncope and/or presyncope) thought
  to be due to an arrhythmia.
• Primary Endpoint Confirmation or exclusion of a
  probable arrhythmic cause of patients symptoms
• Journal Journal of Cardiovascular
  Electrophysiology, Vol. 18, Number 3, March 2007
  Journal of Cardiovascular Electrophysiology
  Online Early doi10.1111/j.1540-8167.2006.00729x
  Volume 0 Issue 0
• Conclusion MCOT provided a significantly higher
  yield than LOOP monitors in patients with
  symptoms suggestive of a significant cardiac
  arrhythmia

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Clinical Trial Results

• Presenting symptoms
• Palpitations 81
• Presyncope 34
• Syncope 16
• Subjects (per protocol)
• CardioNet 134 patients
• LOOP 132 patients
• 114 subjects (43) presented with syncope or
  presyncope
• CardioNet 62 subjects
• LOOP 52 subjects

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Clinical Trial Results
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Clinical Trial Results
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Clinical Trial Results
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Clinical Trial Results
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Clinical Trial Results
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Clinical Trial Results
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Seven More Reasons to Prescribe CardioNet

• Improved Patient Compliance
• Enables you to diagnose and treat sooner.
• CardioNet 24-hour trend graphs and beat-to-beat
  analysis reveal any patient noncompliance.

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Seven More Reasons to Prescribe CardioNet

• Superior Algorithm
• Enables you to diagnose more accurately.
• CardioNet Highly sensitive and accurate. Detects
  by rate, rhythm, and morphology.

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Seven More Reasons to Prescribe CardioNet

• Automatic, Mobile Transmission
• Improves patient compliance greater data
  capture for you.
• CardioNet Symptomatic and asymptomatic events
  are stored and transmitted automatically via
  landline or cellular technology, when in the home
  or away, requiring no patient intervention.

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Seven More Reasons to Prescribe CardioNet

• Analysis and Response 24/7/365 by the CardioNet
  Center
• Be secure knowing trained personnel are
  monitoring your patients. Gives you the ability
  to know precisely how your patients are doing.

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Seven More Reasons to Prescribe CardioNet

• Real-time Symptom/ECG Correlation
• Easy for you to compare and analyze data.
• CardioNet Symptoms reported by patients are
  clearly defined on the CardioNet reports.

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Seven More Reasons to Prescribe CardioNet

• Monitor Memory Storage
• Stores 96 hours of ECG data no event can be lost
  due to memory limitations.
• CardioNet Has the ability to remotely fetch
  ECG data upon physician request.

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Seven More Reasons to Prescribe CardioNet

• Physician Reporting by Internet or Fax
• CardioNet Patient reports delivered to you via
  the Internet or by fax whichever is most
  convenient for you.