Substitution reactions of alkyl halides

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Chapter 8

• Substitution reactions of alkyl halides

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Remember.. (from multistep syntheses)
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Substitution Reactions of Alkyl Halides (8.1)
p 345
The atom or group that is substituted or
eliminated in these reactions is called a leaving
group
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Nucleophilic Substitution Reactions

• Two types
• SN2
• SN1

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SN2

• Substitution Nucleophilic 2-(bi)molecular
• Rate ? R-XNucleophile

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p 348
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p 350
Steric hindrance raises the energy of the
transition state, slowing the reaction
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Substitution Reactions of Alkyl Halides (8.2)
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p 348
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Substitution Reactions of Alkyl Halides (8.2)
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Substitution Reactions of Alkyl Halides (8.2)
p 351
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Substitution Reactions of Alkyl Halides (8.2)
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Substitution Reactions of Alkyl Halides (8.3)
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Reactivity and leaving group abilities in SN2
reactions
p 352
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Substitution Reactions of Alkyl Halides (8.3)
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Nucleophilicity and Basicity
Posted in Semester Book
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I-
pp 353,354
F-
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Substitution Reactions of Alkyl Halides (8.3)
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Substitution Reactions of Alkyl Halides (8.3)
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Substitution Reactions of Alkyl Halides (8.4)