Episodic memory impairments in H1Rknockout mice

1
Episodic memory impairments in H1R-knockout mice

• Armin Zlomuzica
• Institute of Physiological Psychology
• Heinrich-Heine-University
• 40225 Duesseldorf, Germany

2
The central histaminergic system
Arousal
Fear
Awakening
Anxiety
Neural plasticity
Wakefulness
Sleep-wake cycle
Reinforcement
Memory systems
3
The episodic-like memory task
4
Episodic memory deficits in humans Brain
lesions medial temporal lobe (hippocampus)
diencephalic structures frontal cortex
Neurodegenerative and psychiatric diseases
Alzheimer Parkinson Huntington Schizophrenia
5
(No Transcript)
6
(No Transcript)
7
Episodic-like memory deficits in the H1R-KO mice.
Bars represent mean (and sem) preference ratios
of H1R-KO and WT mice. p lt .05, single-group
t test p lt .05, Student t test for unpaired
data p lt .1, Student t test for unpaired data.
Neuroscience, in press
8
(No Transcript)
9
Co-workers E. Dere J. P. Huston M. A. De Souza
Silva S. Binder Experiments were supported by
the Deutsche Forschungsgemeinschaft (DFG) with
grant DE1149 / 2-1 to E.D. and J.P.H.