ISSUES IN QUALITY USE OF MEDICATIONS

1
ISSUES IN QUALITY USEOF MEDICATIONS

• Clinical Sciences 2
• WEEK 1. LECTURE OUTLINE

2
DRUG INTERACTIONS

• Types of interactions
• Drug-drug Drug-food interactions
• Clinical significance Timing of administration
  with respect to meals
• Mechanisms
• Altered Absorption, Distribution, Metabolism and
  Excretion
• Polypharmacy in older adults

3
INDIVIDUAL LIFESPAN FACTORS INFLUENCING DRUG
RESPONSE

• Body surface area / body fat - size
• Age pathophysiology
• Tolerance placebo effect
• Genetics
• Bioavailability
• Pregnancy teratogens
• Pharmacokinetics in neonates, infants elderly

4
PATIENT COMPLIANCE

• Definition significance
• Types of non-compliance
• Contributing factors
• Reasons for non-compliance
• Techniques / strategies in improving compliance
• Patient education

5
DRUG DEVELOPMENT, INFORMATION AND POISONING

• New drug development / standard-drug testing
  procedure
• Sources of information
• Fundamentals of treating poisoning
• Specific antidotes for heavy metals
• Specific antagonists for overdoses of warfarin,
  heparin, insulin and opioids

6
DRUG ABUSE

• Drug abuse definitions
• addiction
• physical dependence
• psychological dependence
• Factors contributing to drug abuse
• Alcohol abuse
• Opioid abuse
• Nicotine smoking