February 17 2005 at 1:30 PM

1
The role of Nod Proteins in Bacterial Detection
Presented by Dana Philpott, Ph.D
Group Leader, Groupe dImmunité Inné et
Signalisation, Département de Biologie
Cellulaire et Infection, Institut Pasteur
February 17 2005 at 130 PM
Dr. Dana Philpott is a candidate for a Joint
Position in Microbial Pathogenesis with the
Laboratory for Foodborne Zoonoses and the
Intestinal Disease Research Program, McMaster
University. Following undergraduate training at
the University of Calgary, Dr. Philpott obtained
her Ph. D at the University of Toronto in 1996
under the supervision of Dr. Phil Sherman. Her
thesis was entitled Signal transduction and
physiological responses to infection with
diarrheagenic Escherichia coli. She went on to
do post-doctoral training with Dr. Mary Perdue at
McMaster (1996/97), and subsequently with Dr.
Philippe Sansonetti (1997/2001) at the Pasteur
Institute, a group that is world renowned for
studies on the pathogenesis of Shigella
infections. Since 2001 she has led the group on
Innate Immunity and Signalling in the Department
of Cell Biology and Infection at that Institute.
The host innate system consists of a limited
number of receptor proteins that recognize
specific pathogens-associated molecular patterns
(PAMPs). Recent studies indicate that there are
two systems of microbial detection the Toll-like
receptors and the Nod receptors. Dr. Philpotts
presentation will focus mostly on her recent
research on the role of Nod receptors in the
detection of bacterial infection by the host.
LFZ Special Lecture

• Dr. Philpott has won many Research Awards and
  Scientific Awards. The latter include
• Prix Charles-Louis de Saulses de Freycinet
  (Institut de France, Academie des Sciences), 2004
• EMBO Young Investigator Award, 2003
• Canadian Society for Microbiology Graduate
  Student of the Year, 1997
• Crohns and Colitis Foundation of Canada Student
  Research prize, 1996
• She has published widely including 12 papers in
  the last 2 years. Recent papers include
• J. Viala et al. Nod1 responds to peptidoglycan
  delivered by the Helicobacter pylori cag
  pathogenicity island. Nature Immunol
  200451166-1174
• D.J. Philpott and S.E. Girardin. The role of
  Toll-like receptors and Nod proteins in bacterial
  infection. Mol. Immunol 2004411099-1108

This seminar is to be held in the Seminar Room
at 110 Stone Road