Eli Lilly

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Eli Lilly Co.
ACTOS For the Treatmeant of Diabetes
By Sharleyne Silcott
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Type 2 Diabetes

• Most common form of the disease
• Insulin resistance (most cases)
• Insulin deficiency
• Secreted by the pancreas
• Insulin transports glucose to the cells
• Glucose builds up in blood
• Cells do not receive sufficient energy

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Photo Researchers, Inc./ Astrid and Hans-Frieder
Michler
Microsoft Corporation
Insulin secretion in the pancreas
Pancreas
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Long Term Effects

• Increased risk for heart disease/stroke
• Kidney disease
• Complications with eyes including blindness
• Neuropathy and nerve damage
• Foot complications
• Skin complications

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Who is at Risk?

• People over the age of 45
• People who are overweight
• People who are inactive
• People with family members with the disease
• People of African, Hispanic or Native American
  decent

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Eli Lilly Co.

• 128 years old
• Headquarters in Indianapolis, Indiana
• Over 46,000 employees worldwide
• Produce products for the treatment of diabetes,
  depression, schizophrenia, ADHD, osteoporosis,
  etc.
• ACTOS produced to treat diabetes

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ACTOS

• Prescription pill for Type 2 diabetes treatment
• Helps the body effectively use natural or
  administered insulin
• Reduces insulin resistance, fasting insulin
  levels and blood glucose

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Thiazolidinediones

• Group of drugs that help people live with
  diabetes (includes ACTOS)
• Help insulin work better in muscle and fat
• Reduce glucose production in the liver
• Can have an adverse affect on the liver
• Frequent blood tests to monitor liver
• Avandia produced by Glaxosmithkline

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Warnings Side Effects

• Symptoms of upper respiratory tract infection,
  headache, sinusitis, muscle soreness, tooth
  disorder and sore throat
• Possible weight gain, swelling and decrease in
  blood count
• Generally well tolerated in clinical trials
• Do not take ACTOS if you have heart problems,
  liver problems, jaundice, have type 1 diabetes
  or are pregnant or breast feeding