Esophageal Strictures

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Esophageal Strictures
William Stanford Leader BSAC Daniel Frost
BWIG Thomas Fleming Communicator Client Dr.
Mark Reichelderfer, MD Advisor Professor John
Webster
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Presentation Outline

• Problem Statement
• Background Information
• Current Methods
• Design Constraints
• Possible Designs
• Future Work

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Background Information

• Esophageal Stricture
• Stomach acid reflux into esophagus forms
  stricture
• Also from cancer, lung problems, and genetics
• Causes heartburn
• Treatment
• Surgery and dilation
• Surgery is complicated and risky
• Dilation is more safe
• Inflatable balloon inside the esophagus

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Background Information

• Stricture Size and Compliance
• Compliance Volume/Pressure
• Little work has been done involving compliance
• Compliance gives information about scar tissue
• Can lead to better treatment options
• Potential correlation between stricture types

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Problem Statement

• Device should
• Measure pressure in balloon
• Measure change in volume of syringe
• Graph volume/pressure curve in real time
• Be aesthetically pleasing for hospital setting
• Eventually be commercially available

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Design Constraints

• Work with current dilation procedure
• Provide real time data
• Provide warning of esophageal perforation
• Software that runs on hospital computers
• Compliance accurate to three significant figures
• Compact enough for hospital setting
• Safety

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Current Prototype

• Syringe is filled with saline
• Pressure measured with pressure transducer
• Volume measured with linear potentiometer
• Outputs are connected to an amplifier circuit
• Circuit connects to computer

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Design 1 LabView

• Advantages
• Real time graphing
• Reads two inputs
• Automatically converts units
• Simple inputs
• Image oriented programming
• Disadvantages
• Complicated
• Time consuming to learn
• Relatively expensive

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Design 2 BioBench

• Advantages
• No programming required
• Has a playback mode
• Multiple inputs
• Less expensive
• Disadvantages
• No real time graphing
• No automatic unit conversion
• Data has to be exported in Microsoft Excel

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Design 3 Pasco

• Advantages
• Real time graphing
• Data can be entered into equations
• Easy to use
• Two inputs
• Least expensive
• Disadvantages
• No support for saline pressure sensor

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Design Matrix
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Future Work

• Write software program for graphing
• Develop amplification circuit
• Testing
• Aesthetic finalization
• Gain IRB approval
• Human testing

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References

• http//sine.ni.com/nips/cds/view/p/lang/en/nid/145
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• http//en.wikipedia.org/wiki/ImageLabview-logo.pn
  g
• http//www.pasco.com
• Hale, A. et. al. (2002). Barostat to Measure
  Esophageal Strictures.
• Kirking, H. et. al. (2002). Barostat to Measure
  Esophageal Strictures.
• Seashore, K. et. al. (2006). Device for Dilating
  Esophageal Strictures.