Teratogenicity PowerPoint PPT Presentations

It is the science dealing with the development of congenital malformations. A teratogen ( terat = monster or ugly animal): It is a substance that alters embryonic or ...

Heavy drinking during pregnancy can result in serious adverse outcomes for the fetus ... fatty acid composition in embryonic chick brains Miller, Teratology 62 :2000. ...

Therefore, NBP, DFA, DFNB and NBA were studied for maternal and postnatal ... NBA Concentrations (mg/m3) AST = Aspartate aminotransferase. RLW = Relative liver weight ...

Panel questions Reproduction and teratogenicity Tumorogenicity Radiographic effectiveness Instructions for use Postmarket studies Reproduction and teratogenicity ...

... Tuberculosis Malignant neoplasms Approach to the patient Drug-drug interactions Ability to ... Teratogenicity Skin rashes--fixed drug eruption ...

At equilibrium, receptor occupancy is related to drug concentration ... Non-dose related - Carcingenesis - impair fertility - Teratogenicity - drug in breast milk ...

When the immune system overreacts, granulomas are formed, leading to a condition known as sarcoidosis. This disorder can cause mild to severe symptoms, or no symptoms at all. This Presentation describes sarcoidosis and gives an overview on Sarcoidosis including causes, symptoms, diagnosis, complications, supplements for sacrcoidosis, and treatment strategies. For more information, please contact us: 9779030507.

Mother Child Adverse Drug Reactions Adverse Drug Reactions Common 6.2% of all hospital admissions 100,000 deaths in the US p.a. Occupy 7 800-bed hospitals in the UK ...

Trauma and Pregnancy

Oral administration of tazarotene in rats (3 to 6 months), dogs (4 to 9 months) ... was not a genotoxic substance, neither was it a carcinogen in rats and mice. ...

DRUG DEVELOPMENT AND CONTROL Chapter 2 Dr. Dipa Brahmbhatt VMD MpH Ms dbrahmbh@yahoo.com

Assigns points according to babies signs or withdrawal every 4-6 hours. Treatment ... Caffeine: Decrease in birth weight, usually associated with smokers who drank 3 ...

Management of IBD in Pregnancy * AZA and its active metabolite, 6-MP, are common choices for maintenance therapy in IBD after other agents have been used to induce ...

Normal physiologic changes of pregnancy may increase maternal risk & alter management. ... Questionnaire study: 7000 dental assistants, 1995 ...

Prescribing in Pregnancy Prof Louise Kenny PhD MRCOG Professor of Obstetrics and Consultant Obstetrician and Gynaecologist Cork University Maternity Hospital

Definition. Epilepsy is a chronic medical condition characterized by 2 or more unprovoked seizures. It is not a disease, it is a syndrome (what is the difference ?

Management of IBD in Pregnancy * AZA and its active metabolite, 6-MP, are common choices for maintenance therapy in IBD after other agents have been used to induce ...

To examine the pharmacist's role and develop a comfort level with respect to ... Likely not teratogenic; cleft lip/palate??? Neonatal withdrawal symptoms ...

Teratology Wendy Chung, MD PhD

She continues IBD medications during pregnancy in combination with folic acid ... Use of safe medications to maintain remission in mother during pregnancy. ...

Tonic- clonic seizures - grand mal - consists of an initial strong contraction ... Tonic- clonic seizures (grand mal) Antiepileptic drugs. clinical use ...

... threatening; can do brain damage to Mom; may directly or indirectly harm fetus as well) ... 'OLD' 'NEW' CARBAMAZEPINE (TEGRETOL, 1974) FELBATOL (FELBAMATE, 1993) ...

Division of Dermatologic and Dental Drug ... informed consent Controlled distribution Historical Overview of Pregnancy Prevention Risk Management Isotretinoin as ...

Understand etiologies of common, non-obstetric surgical occurrences in the pregnant patient ... Barnard et al 1995. Hunter et al 1995. Adenexa ...

Industry concerns on drug usage in pregnant women ... Zidovudine found not to accumulate, and pk similar to non-pregnant adults ...

Title: Author: caoyi Last modified by: caoyi Created Date: 1/5/2004 12:30:53 AM Document presentation format: (4:3)

Niacin as pellagra-preventative factor was identified in 1935, through the ... That niacin is a pellagra-preventative factor is important to the prevention of ...

THE POPPY SEED OF TURKEY AND MEXICO' BLINICK, ET AL. ... Division for State Programs. Substance Abuse and Mental Health Services Administration. SAMSA ...

17 -Hydroxyprogesterone Caproate Injection, 250 mg/mL NDA 21-945 Adeza Biomedical Advisory Committee Meeting Reproductive Health Drugs August 29, 2006

Teratogenic effect is not 100%. Other factors contribute. Genetic susceptibility. If given at a high enough dose even 'benign' agents can be teratogenic. Glucose. 5 ...

Tissue susceptibility changes over time, however usually rapidly dividing ... teratogens may have a molecular component that alters tissue susceptibility ...

Adverse and toxic effects of drugs. Drug interactions (drug-drug) Food and drug interactions ... At least two animal species (one rodent and one non-rodent) ...

Psychiatric Complications of Pregnancy and the Postpartum Joseph Breuner, MD Swedish Family Practice Residency Objectives Appreciate the postpartum period as a time ...

Drug Information questions can be broken down into the following elements: ... 1960's it caused a number of limb deformities due to its teratogenic properties ...

Girls withdrawn. Veronica and Bart. What medications are safe for treating veronica's depression? ... Cohen LS etal. J.Clin Psych 1998:59(suppl 2) Some years later ...

Teratogenic drugs 1. In 60 s, teratogenic effects were recognized: Thalidomide: defects of limb and other organs Valproic acid: Neural tube defects

Metronidazole. Mutagenic in bacteria and carcinogenic in animals ... Metronidazole (Am J Obstet Gynecol ... Metronidazole. Use during lactation controversial ...

Pre-pregnancy Evaluation and Planning: Optimizing Outcome in High-Risk Women Siri L. Kjos, MD Harbor-UCLA Medical Center Preconception Care & Epilepsy Consult Major ...

Mechanisms of Teratogenesis Lynda B. Fawcett, Ph.D. Assistant Professor of Pediatrics Thomas Jefferson University & Alfred I duPont Hospital For Children

Martin H. Huber, M.D. Review of Data from S.M.A.R.T. Program. Susan ... Martin H. Huber, M.D. Vice President and Global Head. Drug Safety Risk Management ...

Pharmacologic Implications for Special Patient Populations: Pregnant Elderly Pediatric Judith A. Kaufmann, Dr PH, FNP-C Associate Professor of Nursing

... used since it is a standard rodent species used in the safety assessment ... on its common use as the non-rodent species in the safety assessment of NCEs ...

... it is murine monoclonal antibody prepared by hybridoma technology and directed against ... selective antibodies therapy ... is a prodrug of ...

Pediatric, Adolescent and Maternal AIDS Branch ... EFV is teratogenic in primates at drug exposures equivalent to humans receiving ...

2 visits to ER with pleuritic CP 'Normal' CXR. Rash, alopecia, mouth ulcers, ... from the early follicular atresia and resulting decreased ovarian reserve. ...

Developmental Toxicology Cause of human birth defects 15-25% genetic cause 4% maternal conditions 3% maternal infections 1-2 deformation (mechanical problem)

Side Effects (remember most immunosuppressant are very toxic) Dose-dependent nephrotoxicity ( Risk of Rejection); enhanced of given with other nephrotoxic drugs ...

Fetal Alcohol Syndrome (FAS) results from prenatal alcohol exposure. ... Astroglial cells by Ethanol: Mechanisms and Implications for Fetal Alcohol Syndrome. ...

Fetal Alcohol Effects lesser effects than full syndrome; may be physically ... Diagnosis of Fetal Alcohol Syndrome. Minimal criteria: Abnormalities in three areas: ...

Rent Unknown Cause (RUC) Not Apparent Etiology Unknown (NAEU) ... Shell, middle (barrier) layer: Diphenyldimethyl-siloxane copolymer, 15 mole% diphenyl ...

... Predisposition to metabolic diseases (i.e. Barker hypothesis - low birthweight associated with increased risk of diabetes, hypertension, ...

ginger supplementation, acupuncture, and. acupressure, may be beneficial. ... Ginger is a nonregulated food product and most preparations ... GINGER ...

Tazarotene Capsules in the Treatment of Psoriasis FDA Advisory Committee Meeting July 12, 2004 Patricia S. Walker MD, PhD Vice President, Skin Care Pharmaceuticals

Although considered one of the safest drugs, it has sedative effects. Many consider them the drugs of choice for seizures only in infants. ...