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THE ENZYMES THAT ASSEMBLE ACETYL-CoA UNITS. USE A DECARBOXYLATION OF MALONYL-CoA ... STARTER. found in grapefruit. flowers, fruit and rind. as the 7-rhamnogylcoside ...
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High throughput gene synthesis and cloning of polyketide synthase ... Azithromycin. Clarithromycin. Erythromycin. Josamycin. Minocycline (Dynacil) Miokamycin ...
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Introduction: Polyketide and Nonribosomal Peptide Natural Products Doxorubicin-Antitumor agent Erythromycin-Antibiotic Cyclosporin-Immunosuppressant
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... enzymes isolated the Asg E locus for ligation. Transformation and Ligation ... Ligation of Asg E gene with vector creates cosmid system for insertion into M. ...
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Epothilone D is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum.
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... 6-deoxyerythronolide B Polyketide production Precursor supply - example Ref: Precursor Supply for Polyketide Biosynthesis: The Role of Crotonyl-CoA Reductase, ...
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THERE ARE TWO CARBONYL GROUPS IN THE 2-UNIT POLYKETIDE CHAIN ... coriander oil. neral. lemon oil. nerol. rose oil. a-terprneol. LPP. OPP- or. b-pinene. a-pinene ...
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Cyanobacterium Synechococcus sp. N2-fixing Rhizobium Mushroom Phellinus linteus Moss Physcomitrella patens Horsetail Equisetum hyemale Polyketide synthase
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... grams of penicillum per liter of culture ... produce polyketide antibiotics Induce recombination by recursive protoplast fusion: Fuse protoplasts ...
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Phenyl propanoid and polyketide, phe+acetate as precursors, 8000 Poppy latex contains morphine and codeine. Dried latex yields opium.
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Mechanism & Genetics of. Polyketide Synthases. These figures, except for the first ... J. Staunton & K. Weissman 'Polyketide biosynthesis: a millenium review ...
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Interest in polyketide macrolide-derived natural products with the skipped ... Srivastava Dr. Jyoti Nandy Dr. Ravi Naga Prasad Dr. Deogratias Ntirampebura ...
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Hungry Fish. 150,000 bites/m2/day. Chemical Defenses of Sponges. Percentage (%) Eaten ... X-Ray Diffraction. CO2. Okadaic Acid is a 'Linear Polyether-Type' Polyketide ...
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... Engineered biosynthesis of polyketide drugs 10:45 Coffee break SESSION I (Chairman: Herbert Kirst) 11:15 IL (2) Hans-Peter Fiedler (T bingen, ...
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... acceptance of genetically modified plants But others are exploiting exactly the flexibility that the SH predicts Polyketide pathway Genetic manipulation ...
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Complex polyketide natural product Not very effective by itself in Phase II trials Was in Phase I and Phase II trials with other cytotoxic drug therapy ...
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... 1 23,099 contig 1 contig 2 contig 5 contig 4 contig 3 %AT 74 50 78 64 71 23,099 kb Scaffold 4FP is at Tox1A PKS1 PKS1 = polyketide synthase Functional analysis ...
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28 What are polyketides and acetogenins. 29 What is the significance of the ... 20 von Braun Reaction. 21 Curtius reaction. 22 Ozonolysis of aromatic rings ...
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The Scope of Transannular oxa-Michael Additions for the Synthesis of Medium ... Laulimalide is a marine sponge-derived polyketide and promising anti-cancer ...
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Enzyme Discovery. Hispidin synthase. Coumaroyltriacetic acid synthase. Horsetail. Equisetum hyemale ... Rhizobium. Moss. Physcomitrella patens. Acyldiacetic ...
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Title: Exploring Nature s total synthesis machinery Author: Greg Challis Last modified by: Challis Created Date: 11/13/2001 11:16:53 AM Document presentation format
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... are made in an assembly-line fashion. Project Goal: Characterize multiple TE Domains ... Time course for protein expression at 30 C shows 10h to be optimal ...
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... phage viruses, and they use them to illuminate the principles that underlie life. ... 1 : explanation of complex life-science processes and phenomena in terms ...
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... 60B1, 62A1, 64A1) fusarin C (at least one P450, CYP627A) fumonisin (2 P450s CYP65 and CYP617 families) ochratoxin A (2 P450s) Lovastatin/compactin (2 P450s, ...
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Approximately 15% of all Rx drugs are based on compounds ... Atropine: isolated from Atropa Belladonna. Anticholenergic agents. Common plant-derived drugs ...
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Title: Vector Hills Template Author: Presentation Helper Last modified by: HP Document presentation format: On-screen Show Other titles: Arial Arial Black Angsana New ...
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Idempotent Vector Design for Standard Assembly of Biobricks, Tom Knight 2001 ... Solar-Powered Sea Slugs. Rumpho et al. Plant Physiol 2000 ...
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... (medicine & drug design). The ... ratio The gyromagnetic ratio is also known as the magnetogyric ratio m m =gI This equation tells us how much magnetism we get ...
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a: estimated using two data points. 12.4. 15.3. 7.75. Substrate 7. 14.0. 1.04. 1.59. Q264A ... mutations E184A , Q264A have high catalytic activity to simple ...
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... response to insect-inflicted damage. The methyl ester of jasmonate is responsible for the characteristic fragrance of jasmine oil, ...
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The AmpliChip CYP450 array from Roche. The first pharmacogenomics diagnostic chip ... Fugu CYP2Y1 and CYP2Y2. Zebrafish CYP2Y3. zebrafish CYP19 and gliomedin ortholog ...
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Peanut STS. Alfalfa CHS. Highly homologous overall structures. Enzyme Structure & Mechanism ... Hydrolysis occurs ONLY during the Cyclization of STS. No ...
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(modified from Wise et al, 1999) nucleus. Cytoplasm. mitochondrion. T-urf13 ... favorable weather. T-cytoplasm corn (genetic homogeneity) Southern Corn. Leaf Blight ...
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Some microbes are difficult or expensive to grow in culture. Strategy: clone the gene for the RE from a ... Animal adhesive proteins (from the blue mussel) ...
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... clan. CYP72 clan. First CYP88 90, 707 seqs. Clan. Family ... CYP71 clan. core eudicot CYPs. core angiosperm CYPs. core land. plant CYPs. Phenylpropanoid pathway ...
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Isolated from sponge in trace amounts. Insufficient material for clinical development ... Two possible mechanisms for oxetane formation. SN2 displacement ...
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A Minnow, an E. Coli and Ubiquinone. 3 x 10-6. 10-13. 3.4 x ... Minnow. RF Fox FNAL 2006. 11. Biological Energy Couplings. Photon energy (electron excitation) ...
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Expression of pederin biosynthesis enzymes from an uncultivated symbiont ... e...elution fraction of purification of MBP. fusion protein. PedI2 PedI3 PedN ...
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Color scheme: PO4 = green; N(CH3)3 = violet; water = blue; terminal CH3 = yellow; ... Sexes male, herm. male, female. Neurons 381, 302 100,000,000,000 ...
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PHENOLS ARE VERY SENSITIVE TO OXIDATION ... Erythrina crista-galli. Arrow poison of South American Indians ('pot curare'); another variety , ...
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RNA2: Last week's take home lessons Clustering by gene and/or condition Distance and similarity measures Clustering & classification Applications
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Fundamentals in Chemical Biology
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The genome of erythromycinproducing Saccharopolyspora erythraea Markiyan Samborskyy and Peter F' Lea
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Fewer than five H-bond donating functions. Fewer than 10 H-bond ... Increase hydrophobicity, decrease water solubility. Increase conformational flexibility ...
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Isolated from sponge in trace amounts. Likely from symbiotic bacteria on sponge ... Pacific marine sponge Cacospongia mycofijiensis. monensin ...
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Typically a process of polymerization, stringing monomers. together into a macromolecule that ... Derived from plants: deadly nightshade (belladonna), mandrake ...
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Title: Phenylpropanoids Author: Name Last modified by: Name Created Date: 3/20/2006 5:01:15 AM Document presentation format
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BBSRC MIBTP Site directed mutagenesis, reverse genetics and complementation Chris Thomas, Joanne Hothersall, Yusra Al-Sammarraie, Mukul Yadav Biosciences, University ...
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facultative. microaerophilic. 1 oxygen requirement. 30. 72. 1 optimal growth ... Facultative anaerobic. Human pathogen: YES. Phenylalanine biosynthesis: ...
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Chemical ecology of tropical algae: Part I
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GH deficiency in children (dwarfism) Erythropoietin. Amgen, Ortho Biotech. Anemia. DNase I ... enzymes in order to create or alter a biochemical pathway ...
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Clone Best Blast hit Putative Function Sim. % pks-2 Microcystis spp. PKS McyE 98 METAGENOMICS OF CYANOBACTERIAL BLOOMS pks-6 Microcystis spp.
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A COMPREHENSIVE AND AN UPDATE DATABASE ON ESSENTIAL FEATURES OF SEMISYNTHETIC ... Ampicillin,Oxacillin,Oxacillin,Cloxacillin,Flucloxacillin,Methicillin, ...
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Model Chemistries. Plastic/Wood Models. Graphical Models. Conceptual Models. Numerical Models ... Models. Chemistry. HPC. Computer- to-Chemist. Interfaces. SAN ...
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Next Friday, 3/15, Dr. David Myles, from Kosan Biosciences ... http://www.daylight.com/dayhtml/smiles/ Summary. Compound Collections and Molecular Diversity ...
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With the discovery of the mechanism of action of Taxol by Susan ... taxol/taxotere. halichondrin. spongistatin. rhizoxin. cryptophycin. sarcodictyin. eleutherobin ...
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