Lectin PowerPoint PPT Presentations

Lectins ... Also known as agglutinins since original discoveries used ... Triticum vulgaris (WGA) - Wheat germ. N-acetylglucosamine (trimers) (chitin) ...

Lectins are glycoproteins or carbohydrate binding proteins having ... Asn125, Gly29, Ala30, and Glu31 in LoLI) form a network of seven hydrogen bonds ...

Lectins The term lectin is a general term that encompasses several families of proteins of non-immune origin that bind glycoconjugates that may or may not have ...

... the animal lectins is based on the classification and curation of lectin families in the 'Genomic Resource for Animal Lectins' by Kurt Drickamer (Imperial College) ...

The Lectin Pathway Originates with Host Proteins Binding Microbial Surfaces Lectin: proteins that bind to a carbohydrate MBL (mannose-binding lectin):

Normal activity on low affinity acceptor ( -MeMan) ... catabolism. Cell turnover. Tissue Destruction. Phagocytosis. Synthesis. Cell proliferation ...

Cucumber Expressed in Transgenic Mosquitoes Impairs Malaria Parasite Development ... Native CEL-III is from the sea cucumber. Figure 5 ...

O-glycosidic linkage is sensitive to alkali (regardless of stereochemistry) b-elimination ... Ribbon drawing of the ppGaNTase-T1 crystal structure. Fritz, ...

Kidney biopsy specimen from patient with membranous nephropathy stained for mannan binding lectin MBL

Definition a plasma protein of hepatic origin, part of the innate immune ... Targets microbial pathogens for destruction via opsonization, enhancement of ...

Alexandra Lambert, MSc. Dendritic cells (DC) play an ... Lumen of vagina. Cervicovaginal. epithelium. Pope M. IAVI 2004. Brenchley et al J. Exp Med 2004 ...

... (ITAM), activating receptor -KLR(killer lectin-like receptor): Heterodimer of CD94 & NKG2 (C type lectin) CD94: short cytoplastic region, no signal ...

Effector cells that mediate delayed-type hypersensitivity (DTH) ... NKR-P1 (a C-type lectin recognizing carbohydrates) Inhibitory Receptors: CD94/NKG2 ...

... by antibody First discovered Alternative pathway Activated by some bacterial cell surfaces Antibody not involved Lectin pathway Activated by mannose binding ...

Complement S. Barbour Suggested Reading: Janeway, Chapter 2, pp. 54-75 Chapter 9, pp. 395-397 ... mannose sugars mannan binding lectin (MBL) -mannan binding lectin ...

... d autres sur les endoth liums Glycoprot ines membranaires qui poss dent un domaine terminal de type lectine Interaction ... est LFA-1 (une int grine de ...

Helicobacter pylori Interaction between a bacterial surface lectin and an oligosaccharide of the gastric epithelium Recognition and adhesion at the cell surface ...

DNA (yellow) was stained with Hoechst 33342. Note how rapid is the collapse of ... This photomicrograph clearly shows that the green-fluorescent lectin staining ...

SCOP structural classification of proteins. ... Root: scop. Class: All beta proteins. Fold: Concanavalin A-like lectins/glucanases ...

... cadherin An adhesion molecule on one cell type binds to a different type of cell adhesion molecule ... NH2-terminal C-type Ca2+ dependent lectin like binding ...

Extracellular Vesicles (EVs) derived from mesenchymal stem cells are known to have therapeutic potential, with several clinical trials ongoing. EV applications to drug delivery platforms have also been developed. Increasing research efforts in the EV field have yielded an appreciation for the potential role of glycans in EV function. TCI can synthesize various glycans related products to support your research, - For Insertion (chemical synthetic oligosaccharide) - For Detection (antibodies and Lectins) - For Cleavage (Enzymes)

La combinaison sp cifique des s lectines, chimiokines et. int grines ... de nombreux osinophiles en combinaison avec d'autres cellules inflammatoires ...

Influenza is a viral respiratory infection ... sialic acid linkages. ... nigra lectin, indicating the presence of sialic acid linked to galactose by an2, ...

... LC 2e HC); binds to mast cells & basophils, high with parasitic worm infection ... http://www.cermav.cnrs.fr/cgi-bin/lectines/menu2.cgi?1C3K ...

Glycomics Lectin array: pros and cons Cons: providing global information about the types of glycan epitopes that are present in the sample but does not give any ...

Plant Lectins: Con A, PHA, WGA, Ricin, and many others ... Binding sequence for antithrombin is a pentasaccharide, a minor subfraction ...

DC-SIGN/HLA-DR+ cells increased in coeliac duodenum Montalvillo E.1, ... DC-SIGN is a C-type lectin and has a high affinity for the ICAM3 molecule.

bond. Carbohydrate. Binding (Lectin) Mechanism of Action Catalytic. QuickTime Movie ... Dr. Julia Levy - Former President and CEO - QLT Inc. Ms. Jeanne Bertonis ...

Recognition is selective for microbes, but not highly specific (pattern recognition). Activation of the Lectin Pathway The soluble plasma protein, ...

Ashwell and Morell 1960s and 1970s. Rapid clearance of desialylated, radioactive ... Lectin BRA-2 (coelomic fluid of acorn barnacle Megabalanus. rosa) ...

TRASDUZIONE DEL SEGNALE DA PARTE DI RECETTORI IMMUNI attivazione C-type lectins ZAP70 Fyn/ Lck ... ITAM E SYK SH3 SH2 KINASE ... proteine favorenti la ...

... 8 8244 146 4 822 12 8167 149 5 828 11 8259 131 6 837 10 8217 124 7 831 13 8266 157 * U-lectin was tested Certified reference ...

Interaction between glycoproteins and lectins studied using AFM. Kateryna Lebed, Joanna Grybos, Grazyna Pyka Fosciak, Malgorzata Lekka, Jan Styczen ...

Protect the interests and fulfill the obligations of South Africa ... Modeccin, Aflatoxin, Volkensin and Viscum album Lectin 1 (Viscumin) REGULATIONS: CHEMICAL ...

Title: Apresenta o do PowerPoint Author: LICCA Last modified by: LICCA Created Date: 11/7/2002 3:04:46 PM Document presentation format: Apresenta o na tela

... CHROMATOGRAPHIC SYSTEM: FPLC (Pharmacia) with LCC-500 Programmer and UV-1 Monitor (278 nm) ELUTION: Equilibrated and eluted with 10 mM phosphate buffer pH: ...

Nucleated cells are harder to lyse. Not particularly effective against tumor cells ... (can't lyse bacteria but seem to control. infections) Early components of ...

Product Biological Effects Regulation Biological properties of C-activation products anaphylactic as C3, but much more potent; attracts & activates PMN causes ...

Safety & QC Dept., M+W Zander Phil. Inc. Blood Type & Diet Linkage Certain foods, and food groups act like poisons to certain blood types. What can be a medicine for ...

Loren Cordain, Ph'D'

Complement functions Host benefit: opsonization to enhance phagocytosis phagocyte attraction and activation lysis of bacteria and infected cells regulation of ...

Parasite Evasion of Host: Perkinsus marinus/Eastern Oyster as a Model Interaction G. Burreson www.disease-watch.com/.../ CD/index/images/pm.jpg

Section 5 the complement system Chapter 1 introduction Complement: history Discovered in 1894 by Bordet It represents lytic activity of fresh serum Its lytic ...

... need to microtome prior to embedding) *Appropriate controls (lack of substrate and/or trapping agent) *Visualization of reaction product ...

Applications of Atomic Force Microscopy and Optical Tweezers in Probing ... Analyzing dynamics between bacterium and cognate host-cell receptor with AFM ...

Lecture 3 Glycan Binding Proteins Principles of Glycan Recognition

Produced by hepatocytes, monocytes and epithelial cells of the gastrointestinal ... Sialic acid found in mammalian cells. inactivates C3b ...

Title: PowerPoint Presentation Author: Steve Krawiec Last modified by: Valued Gateway Client Created Date: 4/2/2003 7:39:40 PM Document presentation format

Click on Programs at the top right of the page and search for ... Horseshoe crab. Limulus polyphemus. N-acetyl-D-Galactosamine. Edible snail. Helix pomatia ...

C3a/4a receptor is expressed by phagocytes, endothelial. cells ... phagocyte. C1qR. Phagocyte recognizes C1q deposited on the surface of apoptotic cell ...

Genetic Engineering Bioethics Who we are University of Chicago iGEM team International Genetically Engineered Machines Competition Create a genetically modified ...

Binding of C1q to antibody activates C1r, C1s protease. C1s. C1r. C1q. Antigen-antibody ... Active serine protease. C3bBb. C4b,2a is classical C3 convertase. ...

The complement system. ???????. Pfeiffer ?? heat labile serum factor ?.?.2437 ... 5.????????? (heat labile) ??????????? 56 ? 30 ????. 6. ????????????? inactive form ...

proteins (synthesized ... complex disease Regulatory protein deficiencies edema RBC lysis Summary The complement system comprises a group of serum proteins ...

Requisites for Successful Growth Attachment Nutrition Survival from host defence Transmission

When enzymatically cleaved, the larger moiety, binds to the activation complex ... EXCEPT C2 (the larger, membrane-binding moiety is C2a; the smaller one is C2b) ...