Interactions Of Sulfonylureas PowerPoint PPT Presentations

Sulfonylureas may interact with Azole antifungals (Fluconazole), Fibrates (Gemfibrozil), Sulphonamides (Trimethoprim), Macrolide antibiotics (Erythromycin), Rifampin, Bosentan, Antacids, Alpha glucosidase inhibitors, Bile-acid binding resins (Colestyramine, colestipol, and colesevelam), ACE inhibitors, Allopurinol and Alcohol.

Pharmacodynamic drug interactions such as receptor mediated and non receptor mediated interactions are dealt in this presentation.

¢ Drug interactions of Meglitinides (Repaglinide & Nateglinide) are dealt in this presentation. ¢ Repaglinide is metabolized by the CYP3A4 and CYP2C8 and hence it interacts with Gemfibrozil, Azole antifungals, Dabrafenib, Montelukast, Macrolide antibiotics and Rifampicin. ¢ Nateglinide is metabolized by CYP2C9 (70%) and CYP3A4 (30%) and it interacts with Amiodarone and Macrolide antibiotics. It also interacts with NSAIDs, MAOIs, Trandolapril, Non selective beta blockers Thiazide diuretics, Corticosteroids, Danazol, Sympathomimetics, Phenytoin and St.John’s wort.

DPP 4 Inhibitors interact with CYP3A4 inducers, CYP3A4 inhibitors and P-Glycoproteins inhibitors.

Alpha-glucosidase inhibitors interact with drugs such as Digoxin, Warfarin, Sulfonylureas, Neomycin, Guar gum, Pancreatin, Amylase, Activated charcoal, Antimuscarinics, Paracetamol and Nifedipine.

Drug interactions of Incretin mimetics (Exenatide) with other drugs like Warfarin, Digoxin, Paracetamol, Antibacterials, Thyroid hormones, Danazol and ACE inhibitors are dealt in this presentation. The interactions of Amylin analogue (Pramlintide) with other drugs such as Alpha glucosidase inhibitors, Danazol, ACE inhibitors, Thyroid hormones, Paracetamol and Antimuscarinics are also dealt in this presentation.

Diabetic patients take Insulin and/or other oral hypoglycemic and antihyperglycemic drugs to control their blood sugar levels. Along with antidiabetic medicines they may take drugs such as OTC medicines, prescription medicines, etc.to treat other illnesses which may interact with them. Drug interactions of Insulin with other drugs like Fluoroquinolones, Betablockers, Aspirin, Thiazolidinediones, Antipsychotics, Androgens, Antimalarials and Orlistat are dealt in this presentation. The interactions of Insulin with Complementary and alternative medicines (CAM) such as Bitter melon, Ginkgo, Ginseng, Gymnema, Licorice and Fenugreek with smoking and with alcohol are also dealt in this presentation.

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Sulfonylureas : stimulate cells to produce more insulin. 1st generation (1)Orinase (tolbutamide) (3)Tolinase (tolazamide) (6)Diabinese (chlorpropamide)

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Ozempic is a medication used for type 2 diabetes and, as a potential side effect, can promote weight loss. It enhances feelings of fullness, leading to reduced food intake. Patients may experience gradual, steady weight loss while effectively managing their blood sugar levels.

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... Cancidas (Caspofungin acetate), an echinocandin, inhibits the synthesis of b-(1,3) glucan via inhibition of the b-(1,3) glucan synthase complex.

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PHARMACOLOGY Simplified, not Mystified The arrival of a good clown exercises a more beneficial influence on the health of a town than 20 asses laden with drugs.