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High-quality coating begins with high-quality tablets, and no coating can achieve peak adherence unless all the tablets in a batch are uniform. When the substrate is prepared properly, tablet coating quality is predictable. A film coating won't hide tablet quality problems and will, in fact, likely magnify quality variations, even when they aren't extreme. This article discusses how variations in tablets - even when in the acceptable range - can affect film coating.

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After making a good tablet, you must often coat it. The coating can have several functions. It can strengthen the tablet, control its release, improve its taste, color it, make it easier to handle and package, and protect it from moisture. This article reviews the basics of tablet coating and describes common tablet coating defects.

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Tablet specifications are tight, and the list of possible defects is long: Variable weight, sticking, picking, black spots, streaks, capping, lamination, variable hardness, among others. This article focuses on variations in tablet weight and tablet hardness. It pinpoints the possible causes of these defects and offers advice on preventing and fixing the source of the problems. It also discusses the problems of formulations with too many fines.

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Sticking occurs when granules attach themselves to the faces of tablet press punches. Picking is a more specific term that describes product sticking only within the letters, logos, or designs on the punch faces. This article explains the causes of sticking and picking and describes the steps you can take to resolve both problems.

Tablet defects bedevil many manufacturers. This article outlines some strategies that tablet production experts use to resolve the most common ones, including weight variation, black spots, capping, and sticking and picking.

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A tablet press is one of the most complex machines used in the manufacturing environment. Clearly defining the basic principles in tablet press operation is essential to having a successful run. Learning key factors can help to avoid the many obstacles that can interrupt a successful run. Worldwide, more than 18 different companies make tablet presses. All tablet presses operate in the same basic way with only a few exceptions. This fact allowed the industry to define and create a standard for tablet press machines and tablet press tooling, which was published in the Tablet Specification Manual (TSM) by the American Pharmaceutical Association. The TSM can be acquired through any tooling or tablet press supplier. This article discusses how tablet press performance can be optimized by clearly distinguishing between granulation and machine issues; focusing on the importance of flow, compression, and ejection; and performing the necessary maintenance and quality control checks.

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