Creativebiogene PowerPoint PPT Presentations

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Aptamer is a term derived from the Latin aptus - fit, and the Greek meros – part. Aptamers are oligonucleic acid or peptide molecules that bind to a specific target molecule. By selecting from a large random sequence pool, we usually can get aptamers, but natural aptamers also are found in riboswitches. To narrow down, aptamers can be classified as: DNA or RNA or XNA aptamers. They consist of (usually short) strands of oligonucleotides. Peptide aptamers. They consist of a short variable peptide domain, attached at both ends to a protein scaffold.

Aptamer is a term derived from the Latin aptus - fit, and the Greek meros – part. Aptamers are oligonucleic acid or peptide molecules that bind to a specific target molecule. By selecting from a large random sequence pool, we usually can get aptamers, but natural aptamers also are found in riboswitches. To narrow down, aptamers can be classified as: DNA or RNA or XNA aptamers. They consist of (usually short) strands of oligonucleotides. Peptide aptamers. They consist of a short variable peptide domain, attached at both ends to a protein scaffold.

It’s hard and time-consuming to complete each single phase of cloning, such as creating custom vectors, handling multiple sequences simultaneously, expressing proteins, using multiple systems etc.

Creative Biogene,Inc is an innovator in developing and supplying world class automated immunohistochemistry (IHC) instrumentation, and the full range of reagents for IHC lab testing.

Retroviruses are negative single-stranded RNA viruses in which tRNA serves as a primer for the mRNA synthesis. The mRNA is then reverse transcribed into DNA, which is then integrated into the chromosome at a multiplicity of sites, particularly those that are transcriptionally active. Retroviral vector-mediated gene transfer has been central to the development of gene therapy. 

Retroviruses are negative single-stranded RNA viruses in which tRNA serves as a primer for the mRNA synthesis. The mRNA is then reverse transcribed into DNA, which is then integrated into the chromosome at a multiplicity of sites, particularly those that are transcriptionally active. Retroviral vector-mediated gene transfer has been central to the development of gene therapy. 

Dating back to 1970s the conceptual emerging, gene therapy trials used to treat human disorders actually really started after twenty years. However like every new thing stumbles, these initial trials did not add color to this exciting and promising field, might because of short of background and related knowledge. So the results at that time were initial dramatic clinical failures.